Infection

Hepatitis C :: 24-week course of interferon-alpha therapy prolongs survival in patients hepatitis C virus

Patients with the hepatitis C virus (HCV) have a risk of frequent recurrence and deterioration of liver function, even after curative treatment for the primary hepatocellular carcinoma (HCC). This unfavorable prognosis is associated with a sustained HCV infection. Thus, both the prevention of HCC recurrence and the preservation of liver function are high priorities when trying to improve the prognosis of patients with HCV-related HCC. Antiviral therapy for chronic hepatitis C (HCV) after treatment for primary HCC is the essential factor required for an improved prognosis.

HIV :: HIV-TB spreads in Africa, undermines control of world’s 2 deadliest infectious diseases

The largely unnoticed collision of the global epidemics of HIV and tuberculosis (TB) has exploded to create a deadly co-epidemic that is rapidly spreading in sub-Saharan Africa. However, health systems cannot adequately diagnose, treat, or contain the co-epidemic due to unanswered scientific and medical questions, according to a report issued today by The Forum for Collaborative HIV Research and amplified by experts from leading global health organizations.

Infertility :: Cow infections could provide clue to preventing infertility in women

Researchers at the Royal Veterinary College, London, have made a significant breakthrough in their understanding of how infection of the uterus damages fertility in cows. Their findings, which show that common uterine infections can damage the ovaries, may provide insights into how to treat infections such as Chlamydia in humans.

MRSA :: MRSA screening essential to stop hospital infections

Betsy McCaughey, Ph.D., Chairman of the Committee to Reduce Infection Deaths (RID) and a former Lt. Governor of New York State, is announcing a model MRSA screening bill and calling on state lawmakers to enact this lifesaving measure. In New York State, the bill will be carried by Assemblywoman Nettie Mayersohn of Flushing, New York. Illinois, Pennsylvania, and New Jersey have already enacted screening bills.

Ear :: Ear infection superbug discovered to be resistant to all pediatric antibiotics

Researchers have discovered a strain of bacteria resistant to all approved drugs used to fight ear infections in children, according to an article published today in the Journal of the American Medical Association (JAMA). A pair of pediatricians discovered the strain because it is their standard practice to perform an uncommon procedure called tympanocentesis (ear tap) on children when several antibiotics fail to clear up their ear infections. The procedure involves puncturing the child’s eardrum and draining fluid to relieve pressure and pain. Analyzing the drained fluid is the only way to describe the bacterial strain causing the infection.

Malaria :: Malaria vaccine candidate has promising safety, tolerability profile in infants

The first study to test GlaxoSmithKline’s (GSK) investigational RTS,S/AS02 malaria vaccine in African infants serves as the first proof of concept in this population that the vaccine has a promising safety and tolerability profile and reduces malaria parasite infection and clinical illness due to malaria, according to a paper published today online in The Lancet.

Urinary Tract Infection :: FDA approves new drug to treat complicated urinary tract and intra-abdominal infections

The U.S. Food and Drug Administration has approved doripenem injection, 500 mg intravenous infusion, for the treatment of complicated urinary tract and intra-abdominal infections. Doripenem injection, sold under the trade name Doribax, has been shown to be active against several strains of bacteria.

Genome :: Consortium Publishes Phase II Map of Human Genetic Variation

The International HapMap Consortium today published analyses of its second-generation map of human genetic variation, which contains three times more markers than the initial version unveiled in 2005. In two papers in the journal Nature, the consortium describes how the higher resolution map offers greater power to detect genetic variants involved in common diseases, explore the structure of human genetic variation and learn how environmental factors, such as infectious agents, have shaped the human genome.