Registry

Immune Disorders :: Wiskott Aldrich syndrome – Transplant

The only treatment that can cure Wiskott Aldrich syndrome – WAS is a bone marrow or cord blood transplant (also called a BMT). A bone marrow or cord blood transplant replaces the abnormal cells in the bone marrow with healthy blood-forming cells from a family member or unrelated donor or cord blood unit. The healthy cells can come from the bone marrow or peripheral (circulating) blood of an adult donor or from the blood collected from the umbilical cord after a baby is born. The transplanted blood-forming cells will make normal platelets, T cells and B cells for the body.

Obesity :: Obesity dramatically increases kidney failure risk

Obesity has long been linked to heart disease, high blood pressure, and diabetes. Now, researchers are adding kidney failure to the list of ailments, as a new research has found that obese people have up to a seven times greater risk of developing end-stage renal disease, more simply known as kidney failure, than normal weight people.

Acne :: Safe use of isotretinoin – accutane for treating severe acne

The U.S. Food and Drug Administration (FDA) is announcing approval of a strengthened distribution program for isotretinoin, called iPLEDGE, aimed at preventing use of the drug during pregnancy. Women who are pregnant or who might become pregnant should not take the drug. Isotretinoin (Accutane and its generics) is a highly effective drug for severe recalcitrant nodular acne, but it carries a significant risk of birth defects if taken during pregnancy.

Diabetes :: Severe hypoglycemia is rare after islet transplantation

Episodes of dangerously low blood glucose, or hypoglycemia, were greatly reduced in people who received an islet transplant for poorly controlled type 1 diabetes, according to an analysis of outcomes in 138 patients who had the procedure at 19 medical centers in the United States and Canada. This is one of the conclusions of the Collaborative Islet Transplant Registry (CITR), which tracks many factors affecting the success of this experimental procedure in people with severe type 1 diabetes.