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Gene :: How blood flow dictates gene expression

Researchers at the University of Pennsylvania School of Medicine have pinpointed a key regulatory protein that translates blood flow into gene expression. The investigators showed that in a model of mouse embryonic development a transcription factor called Klf2, which resides in cells that line blood vessels, is activated by rapid, pulsed blood flow. Understanding Klf2’s role in blood vessel and muscle biology could help with fighting atherosclerosis.

Climate :: New evidence shows New Madrid Seismic Zone may be cold and dying

New results about the temperatures of rock deep below the New Madrid Seismic Zone in the central United States shed light on the puzzling questions of why large earthquakes happened there in 1811 and 1812 and when they may happen again.

Geology :: January-February 2007 GSA BULLETIN media highlights

Geology topics of interest include: Two New Zealand supervolcanoes that erupted only days or weeks apart; remarkably detailed K-T boundary evidence from the tropical Atlantic’s Demerara Rise supporting a single impact event; and human impact on continental erosion and sedimentation.

Neuroscience :: Humpback whales have brain cells also found in humans

A new study compared a humpback whale brain with brains from several other cetacean species and found the presence of a certain type of neuron cell that is also found in humans. This suggests that certain cetaceans and hominids may have evolved side by side.

Historic volcanic eruption shrunk the mighty Nile River

Volcanic eruptions in high latitudes can greatly alter climate and distant river flows, including the Nile, according to a recent study funded in part by NASA.

Lewis and Clark data show narrower, more flood-prone river

A geologist at Washington University in St. Louis and his collaborator at Oxford University have interpreted data that Lewis and Clark collected during their famous expedition and found that the Missouri River has markedly narrowed and its water levels have become more variable over the past two hundred years.

Salmonellosis :: Recent update on salmonella infection

This is an update of previously posted information on a multistate outbreak of Salmonella Typhimurium caused by a unique molecular strain of this bacterium. This infection has no relationship to typhoid fever, which is caused by another bacterium. Persons infected with Salmonella Typhimurium typically have fever and diarrhea that resolve after about one week.

Health :: Highest Honor awarded to infectious disease experts from Harvard School of Public Health

Harvard School of Public Health (HSPH) has awarded its highest honor, for the promotion of high public health standards among vulnerable populations, to William H. Foege, former Director of the U.S. Centers for Disease Control and a founder of the Task Force for Child Survival and Development, and Anthony S. Fauci, Director of the National Institute of Allergy and Infectious Diseases (NIAID). The two recipients have dedicated their lives to protecting people in this country and throughout the world from infectious diseases.

ADHD :: Lisdexamfetamine dimesylate in ADHD phase 3 data presented

Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) and its collaborative partner New River Pharmaceuticals Inc. (NASDAQ: NRPH) announced today that their investigational ADHD treatment, lisdexamfetamine dimesylate (also known as NRP104 or LDX), yielded a 60 percent improvement in the primary rating scale scores for symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 6 to 12 years who received six months of treatment in an open-label phase III study. Results also demonstrated that at 6 months, 95 percent of children taking lisdexamfetamine dimesylate (NRP104/LDX) produced a “much improved” or “very much improved” rating on the Clinical Global Impressions ? Improvement score. These results were presented last weekend at a national meeting of child and adolescent psychiatrists.

Health :: New approach to treat neglected tropical diseases

World Health Organization (WHO) and a group of more than 25 partner organizations unveiled a new strategy to fight some of the most neglected tropical diseases that destroy the lives and health of poor people.