Lymphoma :: Novel gallium compound offers treatment for lymphoma patients with resistant disease

Christopher Chitambar, M.D., a physician researcher at the Medical College of Wisconsin Cancer Center in Milwaukee, has identified a compound that may be effective in treating forms of non-Hodgkin’s lymphoma (a cancer of the lymphatic system) that are resistant to certain therapies. The new agent could also offer the advantages of being administered orally, rather than intravenously, making it more convenient than intravenous agents.

Cancer :: AVN944 inhibits IMPDH & induces apoptosis-related biomarkers in patients with hematologic cancers

IMPDH is highly upregulated in most hematological cancers and solid tumors — an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function — believed to result in tumor cell apoptosis at the right doses.

Unusually stable glasses may benefit drugs, coatings

A new approach to making remarkably stable glassy materials from organic molecules, developed by researchers from the University of Wisconsin-Madison and the NIST Center for Neutron Research, could lead to novel coatings and to improvements in drug delivery.

Eli Lilly sees 2007 Profit

Pharmaceutical company Eli Lilly and Co. (LLY) reaffirmed its earnings and sales outlook for fiscal 2006 and provided guidance for fiscal 2007.

Bioprospecting not biopiracy

By training professionals in high-biodiversity regions to advance the drug discovery process in-country, a novel program drives drug discovery costs down as it promotes tropical biodiversity conservation. An international team describes a successful test of the program in Panama in the December, 2006 issue of BioScience.

Biovail :: Biovail Corp. follows through on major restructuring

Biovail Corporation (NYSE:BVF)(TSX:BVF) today announced that, effective immediately, Kenneth G. Howling has been promoted to Senior Vice-President, Chief Financial Officer. Charles Rowland, Biovail’s former Senior Vice-President, Chief Financial Officer has left the firm to assume a senior position with another pharmaceutical company.

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