Urinary Tract Infection :: Treatments for urinary infections leave bacteria bald, happy and vulnerable

A different approach to treating urinary tract infections (UTIs) could defeat the bacteria that cause the infections without directly killing them, a strategy that could help slow the growth of antibiotic-resistant infections. Researchers at Washington University School of Medicine in St. Louis have been working to create pharmaceuticals that essentially “defang” the bacteria by preventing them from assembling pili, microscopic hairs that enable the bacteria to invade host cells.

Botulinum :: Seeing a neurotoxin’s deadly grip

Two Howard Hughes Medical Institute (HHMI) research teams working independently have discovered new information about how the botulinum neurotoxin shuts down neurons with deadly efficiency. By providing detailed views of the toxin plugged into its neuronal receptor, the new studies could aid efforts to engineer specialized versions of the powerful neurotoxin that is used to treat a wide array of medical problems.

Hepatitis :: Abbott, Enanta to Develop and Commercialize HCV Protease Inhibitors

Abbott and Enanta Pharmaceuticals announced today that the companies have signed a worldwide agreement to develop and commercialize hepatitis C virus (HCV) NS3 and NS3/4A protease inhibitors. Enanta has discovered several HCV protease inhibitors that have demonstrated attractive efficacy and pharmacokinetic profiles in pre-clinical studies.

Healthcare :: Licensing Opportunities for Rare Disease Technologies

The National Institutes of Health (NIH) launched a new website today offering technologies available for commercial licensing that are related to rare diseases or conditions. The listing can be found at http://www.ott.nih.gov/rarediseases and currently consists of more than 500 such technologies, including drugs, biologics, and devices, available to be transferred from the NIH and the U.S. Food and Drug Administration (FDA) to the private sector for further research and development and potential commercialization.

Malaria :: Stop marketing unapproved drug products containing quinine – FDA

The Food and Drug Administration (FDA) today ordered firms to stop marketing unapproved drug products containing quinine, a drug used to treat malaria, citing serious safety concerns, including deaths, associated with quinine products. There are multiple unapproved products containing quinine currently marketed. However, there is only one quinine product approved by the FDA.

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