Although there are wide claims about the benefits of antioxidants for wrinkles when used in skin creams, to date, only vitamins E and C and selenium applied topically have been proven to have any benefits for reducing sun damage in the skin. Even with these antioxidants, however, most available brands contain very low concentrations of them. In addition, they are also not well absorbed and they have a short-term effect. New delivery techniques, however, may prove to offset some of these problems.
Vitamin C, or ascorbic acid. This is a very potent antioxidant and most studies on the effects of antioxidants on the skin have used this vitamin. In laboratory studies, large amounts reduced skin swelling and protected immune factors from sunlight. It may even promote collagen production. Vitamin C by itself is unstable, but products that solve the delivery problem are now available (e.g., Cellex-C, Avon’s Anew Formula C Treatment Capsules, and others). One 2002 study using Cellex-C reported reduction in wrinkles around the mouth, on the cheek, and around the eyes. The product also appeared to improve skin thickness.
Vitamin E. Studies suggest that topical vitamin E, particularly alpha tocopherol (a form of vitamin E) cream decreased skin roughness, length of facial lines, and wrinkle depth. Studies on mice have also reported reductions in UV-induced skin cancer with its use.
Selenium. In the form of L-selenomethionine, selenium has protected against sun damage and even delayed skin cancer in animal studies. It is not known if such benefits apply to people.
One 1999 study found that topical application of the antioxidant Coenzyme Q10 (CoQ10) improved the skin’s resistance to the oxidative stress of UV radiation, and when applied long-term, could reduce crow’s feet.