Schizophrenia :: How schizophrenia develops, major clues discovered

Schizophrenia may occur, in part, because of a problem in an intermittent on/off switch for a gene involved in making a key chemical messenger in the brain, scientists have found in a study of human brain tissue. The researchers found that the gene is turned on at increasingly high rates during normal development of the prefrontal cortex, the part of the brain involved in higher functions like thinking and decision-making — but that this normal increase may not occur in people with schizophrenia.

Drug :: Computational modeling could improve antibody drugs

Scientists have developed computational models that could improve the effectiveness of drugs based on antibodies. By calculating which molecular changes would cause the antibodies to bind more tightly to their targets, the models already have helped create a new version of an anticancer drug.

Flu :: No Vacation for Flu Virus

It’s almost flu season, so keep washing your hands and get a flu shot. But no matter how well we prepare, the virus stays one step ahead. Researchers now think that’s because the flu virus doesn’t vacation—it remains on duty throughout the year, traveling the globe and mixing with other strains.

Cancer :: CD8+ T cells LAG behind

New data generated using mice by Charles Drake and colleagues at Johns Hopkins University School of Medicine, Baltimore, have identified a role for the protein LAG-3 in limiting the response of immune cells known as CD8+ T cells to both host and tumor proteins.

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