University of South Florida researchers report that a novel needle-free vaccine approach is effective and safe in clearing brain-damaging plaques from a mouse model of Alzheimer’s disease.
The transdermal, or across the skin, vaccination, may offer a simpler way of preventing or treating the devastating neurodegenerative disease with less likelihood of adverse immune reactions.
The study was published online this week in The Proceedings of the National Academy of Sciences.
“While many groups have shown vaccinating against the beta amyloid protein (Ab) can reduce Alzheimer’s-like pathology including certain cognitive deficits, this study is the first to demonstrate that immunization using the skin may be an effective way to reduce Ab pathology,” said senior study author Jun Tan, PhD, MD, director of the Neuroimmunology Laboratory at the Institute for Research in Psychiatry, USF Department of Psychiatry.
“The beauty is that something as simple and non-invasive as a skin patch could potentially be a promising therapy for Alzheimer’s disease,” said study coauthor Terrence Town, PhD.
The Alzheimer’s vaccine works by triggering the immune system to recognize Ab — a protein that abnormally builds up in the brains of Alzheimer’s patients ? as a foreign invader and attack it.