The lungs of patients suffering chronic obstructive pulmonary disease (COPD) attempt to repair damaged elastic fibers, a new finding that contradicts the conventional wisdom on the capabilities of the adult lung. The researchers found that synthesis of elastin, a gene linked to elastic fiber growth, is increased in the moderately diseased tissue of COPD patients. Elastic fibers allow the lung to expand and contract with breathing.
The heart health benefits of omega-3 fatty acids — found in salmon, tuna and other cold-water fish — have long been touted. But according to the November issue of Mayo Clinic Women’s HealthSource, new research indicates that omega-3 fats might not be as beneficial as previously believed.
Scientists supported by the National Institute of Dental and Craniofacial Research, part of the National Institutes of Health, report in this week?s New England Journal of Medicine that pregnant women who received non-surgical treatment for their periodontal, or gum, disease did not also significantly lower their risk of delivering a premature or low-birthweight baby.
Researchers have used a single compound to increase the lifespan of obese mice, and found that the drug reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets–some of which are associated with diabetes, heart disease, and other significant diseases related to obesity. The research, led by investigators at Harvard Medical School and the National Institute on Aging, is the first time that the small molecule resveratrol has been shown to offer survival benefits in a mammal. The study is reported in the November 1 advanced online edition of Nature.
By combining four proteins of Staphylococcus aureus that individually generated the strongest immune response in mice, scientists have created a vaccine that significantly protects the animals from diverse strains of the bacterium that cause disease in humans. A report describing the University of Chicago study, funded by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health, appears online this week in the Proceedings of the National Academy of Sciences.
The Office of Research on Women?s Health (ORWH) and the Trans-NIH Working Group for Research in Chronic Fatigue Syndrome (CFSWG) of the National Institutes of Health (NIH) are pleased to announce seven (7) awards in Chronic Fatigue Syndrome (CFS) research. The proposed studies will help researchers understand how the diverse symptoms in CFS are related to the interactions between the immune and neurological systems ? an important step towards developing effective treatments for a disabling condition.
If drug therapy can’t open blocked sinuses, sufferers now have a novel option. Mayo Clinic ear, nose and throat (ENT) surgeons have taken a page from the book of cardiology in performing a new, outpatient procedure to alleviate acute or chronic symptoms of sinusitis, an inflammation of the sinus cavities usually due to an infection.
GlaxoSmithKline plc [NYSE:GSK, LSE:GSK] announced results from a global Phase II study of eltrombopag, an investigational non-peptide oral platelet growth factor. In this study of 74 hepatitis C patients with thrombocytopenia, (a condition where the blood has low platelet levels) more than 95% (p< 0.001) of patients treated with the highest dose of eltrombopag (75mg) had increased platelet counts. In addition, 71% - 91% of patients in all treatment groups were able to initiate antiviral therapy with pegylated interferon-α (IFN) and ribavirin, and 65% were able to be maintained on therapy.1 Full results from this Phase II study are being presented today at the 57th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston, Massachusetts.
In a new clinical practice guideline, the American Academy of Pediatrics (AAP) outlines recommendations for diagnosing and managing bronchiolitis, the most common lower respiratory infection in children under age 2. The symptoms of bronchiolitis often mirror those of asthma or bacterial pneumonia, resulting in misdiagnosis and incorrect treatment.
An ancient spice, long used in traditional Asian medicine, may hold promise for the prevention of both rheumatoid arthritis and osteoporosis, according to a recently completed study at The University of Arizona College of Medicine. Turmeric, the spice that flavors and gives its yellow color to many curries and other foods, has been used for centuries by practitioners of Ayurvedic medicine to treat inflammatory disorders. Turmeric extract containing the ingredient curcumin is marketed widely in the Western world as a dietary supplement for the treatment and prevention of a variety of disorders, including arthritis.