Heart Disease :: GlaxoSmithKline’s COREG, carvedilol phosphate for cardiovascular conditions

GlaxoSmithKline (NYSE: GSK) and Flamel Technologies (NASDAQ:FLML) announced FDA approval of once-a-day Coreg CR (carvedilol phosphate) extended-release capsules, for the treatment of three cardiovascular conditions: 1. High blood pressure, also known as hypertension. 2. A heart attack that has reduced how well the heart pumps (known medically as post-myocardial infarction left ventricular dysfunction). 3. Mild to severe heart failure.

HIV :: REYATAZ, atazanavir sulfate for Adults With HIV-1 Infection

Bristol-Myers Squibb Company (NYSE: BMY) announced that the U.S. Food and Drug Administration (FDA) has granted approval of a new 300 mg single capsule formulation of REYATAZ? (atazanavir sulfate) for the treatment of HIV-1 infection in adults as part of combination therapy. Taken once daily along with ritonavir and food as part of a anti-HIV drug regimen, the REYATAZ 300 mg single capsule formulation can replace two REYATAZ 150 mg capsules for: patients who have previously received anti-HIV medicines, patients who will be receiving tenofovir disoproxil fumarate, and patients who have never taken anti-HIV medicines that require SUSTIVA? (efavirenz) as part of their anti-HIV drug regimen. The REYATAZ single capsule formulation will be available in the United States within seven business days.

Hunter Syndrome :: ELAPRASE, idursulfase – therapy for Hunter syndrome patients in Europe

Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ) today reported that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) issued a positive opinion recommending approval of ELAPRASE for the long-term treatment of patients with Hunter syndrome (Mucopolysaccharidosis II). The EU Marketing Authorisation is expected early in 2007 and will result in unified labelling that will be valid in the current EU 25 member states as well as in Iceland and Norway.

Heart Disease :: Dilated cardiomyopathy – child heart disease due to inflammation

Researchers have uncovered partial causes for dilated cardiomyopathy, a form of potentially fatal child heart disease that often goes undetected. DCM means the heart fails to pump properly and the condition can often lead to heart failure. The US research, published in the Journal of the American Medical Association, found heart inflammation is the most common cause.

Stroke :: Surgery Better Than Stents

Surgery outperformed the use of stents in a French trial of patients who had warning symptoms of stroke because of blockage of the carotid arteries, the main blood vessels to the brain. Indeed, the trial was cut short “for reasons of both safety and futility,” said a report in the Oct. 19 issue of the New England Journal of Medicine. The incidence of stroke or death in the 30 days and six months after a procedure was about twice as high for patients given a stent, a tube-like device to keep an artery open, than for those who had the surgery called endarterectomy.

Success :: Blueprint for Success – Defining Your Goals

Goal means what your aim to reach in the future. In your life establishing goals has a positive impact. A goal is a specific, assessable result that you want to generate at a determinable time in the future. But if what you hope to achieve in life is based on your expectations, rather than on working to reach established goals. Your goals are the stepping-stones toward the understanding of your dreams, the second key element in the blueprint of your life.

Heart Disease :: Ivabradine – treatment for individuals with angina, stable angina

Heart rate reduction is the cornerstone of the treatment of angina. To date, β-blockers have been the best drugs with which to achieve this. Heart rate is set by the pacemaker cells in the sinus node. Specific cardiac ion channels, f-channels, have been identified that control the rate at which these pacemaker cells initiate cardiac contraction. A selective and specific f-channel (f) current inhibitor, ivabradine, has now been developed that reduces heart rate to a degree similar to that achieved with β-blockers, but without their side effects. Ivabradine is now available for clinical use and promises to be a major and exciting treatment for individuals with angina.

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