Heart Disease :: MEDAL – No increase in cardiovascular events with COX-2 inhibitor
Researchers in the randomized Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program found identical rates of thrombotic cardiovascular events in patients with osteoarthritis or rheumatoid arthritis treated with either the COX-2 inhibitor or the traditional NSAID. Christopher Cannon, M.D., an associate professor of medicine at Harvard Medical School, Boston, noted that this appears to contradict earlier observational studies associating COX-2 inhibitors with higher rates of thrombotic cardiovascular events.