Dr. Alan List, from the H. Lee Moffitt Cancer Center & Research Institute, presented the final results from a pivotal Phase II trial evaluating Revlimid in patients with an incurable blood cancer known as myelodysplastic syndromes (MDS) at this year’s American Society of Hematology (ASH) meeting.
IMPDH is highly upregulated in most hematological cancers and solid tumors — an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function — believed to result in tumor cell apoptosis at the right doses.
A new study has found that close to half of 154 smokers who had surgery to remove early stage lung cancer picked up a cigarette again within 12 months of their potentially curative operation, and more than one-third were smoking at the one year mark. Sixty percent of patients who started smoking again did so within two months of surgery.
Cancer immunoresistance may be partially due to loss of a well-known tumor suppressor gene, according to new research led by Andrew T. Parsa, MD, PhD, assistant professor of neurological surgery at the University of California, San Francisco.
Scientists at the Mayo Clinic in Minnesota found that taking aspirin and other similar painkillers, may reduce the risk of developing an enlarged prostate by at least 50 percent.
Cancer Research UK today put Britain on a warning that the rising tide of obesity could result in as many as 12,000 cases of weight related cancer diagnosed annually by 2010.
The popular hair-growth drug Propecia? taken by millions of balding men, artificially lowers the results of the prostate-specific antigen (PSA) test, the standard screening test for prostate cancer, researchers report.
Sildenafil and other “impotence drugs” that boost the production of a gassy chemical messenger to dilate blood vessels and produce an erection now also show promise in unmasking cancer cells so that the immune system can recognize and attack them, say scientists at the Johns Hopkins Kimmel Cancer Center.
University of Pennsylvania alumni Ralph J. Roberts and his son Brian L. Roberts have pledged $15 million to help create the first-of-its-kind proton therapy center for the treatment of cancer.
No increased incidence of cancer among mobile phone users, revealed in a long-term study, carried out by the Institute of Cancer Epidemiology in Denmark and published in the Journal of the National Cancer Institute.