Glycogen Storage Disease :: Glycogen Storage Disease Type V n Homeopathy

The phosphorylase enzyme plays a vital role in the breakdown of glycogen into glucose. In the absence of phosphorylase in muscles, glucose can not be released from the glycogen stored in skeletal muscles to create energy. People with Type V GSD experience problems performing and completing most exercises, especially anaerobic exercises. Because they lack the enzyme to metabolize glycogen, which is the main source of energy for anaerobic activity, their body struggles to find other sources of energy to complete a given activity or exercise.

Synonyms:
Myophosphorylase Deficiency
Muscle Phosphorylase Deficiency
McArdle Disease

Under these circumstances, the body breaks down muscle when trying to attain energy. This causes many symptoms such as muscle pain, muscle cramping, muscle fatigue, and muscle tenderness. With the breakdown of muscle (rhabdomyolysis) and the release of the red protein myoglobin, myoglobinuria may develop, as evidenced by dark-red or red-brown urine. Serum creatine kinase levels will be greatly elevated.

GENERALS – WEAKNESS – muscular

acon.;1 _ agar.;1 _ alum.;1 _ alumn.;1 _ alumn.;1 _ am-c.;1 _ am-m.;1 _ anac.;1 _ ant-c.;1 _ arn.;1 _ arn.;1 _ ars.;1 _ asaf.;1 _ aur.;1 _ bar-c.;3 _ bar-m.;1 _ bar-m. _ bell.;1 _ berb.;1 _ bry.;1 _ calc.;2 _ calc. _ cann-s.;1 _ canth.;1 _ carb-ac.;2 _ carb-v.;2 _ caust.;1 _ cham.;1 _ chin.;2 _ chlol.;2 _ chlol.1 _ cimic.;1 _ cocc.;1 _ cocc.;1 _ colch.;1 _ con.;2 _ cortico.;1 _ cortico.;1 _ croc.;2 _ dig.;2 _ dros.;1 _ dulc.;2 _ euphr.;1 _ ferr.;2 _ ferr-m.;1 _ ferr-m. _ ferr-p.;1 _ gels.;3 _ gels. _ graph.;1 _ hyos.;1 _ iod.;1 _ kali-bi.;1 _ kali-c.;1 _ kali-n.;1 _ kali-p.;2 _ laur.;1 _ lyc.;2 _ macro.;1 _ macro.;1 _ macro.;1 _ mag-c.;1 _ mag-m.;1 _ mag-p.;1 _ mang.;1 _ meny.;1 _ merc.;1 _ mez.;1 _ mur-ac.;1 _ mur-ac.;1 _ nat-c.;2 _ nat-m.;3 _ nat-m.;3 _ nit-ac.;3 _ nux-v.;1 _ olnd.;1 _ op.;2 _ op. _ petr.;1 _ ph-ac.;1 _ ph-ac.;12 _ phos.;1 _ phys.;1 _ phys.;1 _ pic-ac.;3 _ pic-ac.;3 _ pic-ac.2 _ plat.;2 _ plb.;2 _ plb. _ plb.;21 _ puls.;1 _ rad-br.;1 _ rheum;1 _ rhod.;2 _ sabad.;1 _ sabad.;1 _ sabad.;1 _ sarcol-ac.;1 _ sarcol-ac.;1 _ sec.;1 _ sep.;2 _ sil.;2 _ sin-n.;1 _ sin-n. _ spig.;1 _ stann.;1 _ stram.;1 _ stront-c.;1 _ sul-ac.;1 _ sulph.;2 _ ter.;1 _ ter. _ thuj.;1 _ verat.;2 _ verat. _ verat-v.;1 _ zinc.;1

GENERALS – PAIN – Muscles, of

achy.;1 _ achy.;1 _ acon.;2 _ agav-t.;1 _ agav-t.;1 _ alet.;1 _ am-caust.;1 _ am-caust.;1 _ ant-t.;2 _ arn.;2 _ arn.;21 _ ars.;1 _ aster.;1 _ aster.;1 _ bell.;1 _ bell-p.;1 _ bell-p.;1 _ brach.;1 _ brach.;1 _ bry.;2 _ bry.;21 _ carbn-s.;1 _ caust.;2 _ caust.;2 _ cimic.;2 _ colch.;2 _ colch.;2 _ dulc.;2 _ dulc.;21 _ eryt-j.;1 _ eryt-j.;1 _ ferr-p.;1 _ ferr-p.;1 _ form.;1 _ form.;1 _ gels.;2 _ gels.;2 _ harp.;1 _ harp.;1 _ hist.;1 _ hist.;1 _ ign.;1 _ ign.;1 _ lat-m.;1 _ lat-m.;1 _ led.;1 _ lyc.;1 _ lyc.;1 _ macro.;2 _ mag-s.;1 _ mag-s.;1 _ mag-s.;1 _ mand.;1 _ mand.;1 _ mand.;1 _ merc.;1 _ merc-c.;1 _ merc-c.;1 _ morph.;1 _ nat-f.;1 _ nat-f.;1 _ nat-f.;1 _ nat-m.;1 _ nat-m.;1 _ nat-m.;1 _ op.;1 _ op.;1 _ phyt.;2 _ phyt.;2 _ plb.;1 _ plb.;1 _ puls.;1 _ puls.;1 _ ran-b.;2 _ rauw.;1 _ rauw.;1 _ rham-cal.;1 _ rham-cath.;1 _ rhus-t.;2 _ rhus-t.;21 _ ruta;2 _ sal-ac.;1 _ sil.;1 _ sil.;11 _ staph.;1 _ staph.;11 _ stram.;1 _ stroph-s.;1 _ stroph-s.;1 _ stry.;2 _ stry.;2 _ sulfa.;1 _ sulfa.;1 _ tab.;1 _ tab.;1 _ tarax.;1 _ tarax.;1 _ thal.;1 _ thal.;1 _ thal.;11 _ thuj.;1 _ thuj.;1 _ valer.;1 _ verat.;2 _ verat.;2 _ verat.;2 _ verat-v.;2 _ zinc.;1 _ zinc.;1

GENERALS – DEGENERATION of tissues, tendency to
arn.;1

GENERALS – PAIN – cramping – muscles, in

acon.;1 _ agar.;1 _ alum.;1 _ am-c.;1 _ am-m.;1 _ ambr.;2 _ anac.;3 _ anac. _ ang.;3 _ arg-met.;1 _ arn.;2 _ ars.;2 _ asaf.;1 _ asar.;1 _ asar.;1 _ aur.;1 _ bar-c.;1 _ bell.;3 _ bell.;32 _ bism.;1 _ bov.;1 _ bry.;1 _ bufo;1 _ calc.;3 _ camph.;1 _ camph. _ cann-s.;2 _ caps.;1 _ carb-an.;1 _ carb-v.;1 _ carbn-s.;1 _ carbn-s.;1 _ castm. _ caust.;2 _ caust. _ cham.;2 _ chin.;1 _ cic.;1 _ cimic.;1 _ cimic.;1 _ cina;3 _ clem.;1 _ cocc.;2 _ cocc. _ colch.;1 _ coloc.;3 _ coloc. _ con.;2 _ conin.;1 _ conin.;1 _ croc.;1 _ cupr.;3 _ cupr. _ cupr-act.;2 _ cupr-act. _ cyt-l.;1 _ cyt-l.;1 _ dig.;1 _ dios.;2 _ dios. _ dros.;1 _ dulc.;2 _ euph.;1 _ euphr.;2 _ ferr.;1 _ gels.;1 _ gels. _ graph.;2 _ graph. _ haliae-lc.;1 _ hell.;1 _ hep.;1 _ hist.;1 _ hist.;1 _ hyos.;1 _ ign. _ ign.;2 _ iod.;1 _ ip.;1 _ iris _ kali-br. _ kali-br.;2 _ kali-c.;2 _ kali-n.;1 _ kreos.;1 _ lach.;1 _ lat-m.;1 _ lat-m.;1 _ lyc.;3 _ mag-c.;1 _ mag-m.;1 _ mag-p.;2 _ mag-p.;2 _ mang.;1 _ meny.;1 _ merc.;3 _ mez.;1 _ morph.;1 _ morph.;1 _ mosch.;1 _ mur-ac.;2 _ nat-c.;1 _ nat-f.;1 _ nat-f.;1 _ nat-m.;1 _ nit-ac.;2 _ nux-m.;1 _ nux-v. _ nux-v.;3 _ olnd.;1 _ op. _ op.;21 _ op.;2 _ petr.;2 _ ph-ac.;1 _ phos.;1 _ phyt.;12 _ phyt.;11 _ phyt.;1 _ plat.;3 _ plb.;2 _ plb. _ plb.;2 _ puls.;1 _ puls.;1 _ ran-b.;1 _ rheum;1 _ rhod.;1 _ rhus-t.;2 _ ruta;1 _ sabad.;1 _ samb.;1 _ sang.;1 _ sarcol-ac.;1 _ sarcol-ac.;1 _ sec.;2 _ sep.;3 _ sil.;3 _ spig.;2 _ spong.;2 _ squil.;1 _ stann.;2 _ staph.;1 _ stram.;1 _ stront-c.;1 _ sul-ac.;3 _ sulph.;3 _ tab.;2 _ tab.;2 _ tab.;2 _ thuj.;2 _ valer.;2 _ verat.;3 _ verb.;2 _ viol-o.;1 _ viol-t.;1 _ zinc.;1 _ zinc.

The physical exam of patients with Type V glycogen storage is normal. They complain of painful muscle cramps after exercise. These persons are commonly muscular; they do not have large livers, and are normal in height. Their liver phophorylase activity is normal, and they do not have hypoglycemia. A muscle biopsy will show increased concentrations of glycogen, and a deficiency of the phosphorylase enzyme.

At present, there is no specific treatment for this type of GSD. It is very important for patients to exercise only moderately, for extensive exercise can cause considerable muscle breakdown resulting in a great deal of myoglobin in the urine. Large amounts of myoglobin may precipitate in the kidneys and cause temporary kidney failure. Some patients have developed significant muscle problems (myopathies) later in life.

Dr. Rajneesh Kumar Sharma
Homoeo Cure & Research Centre P. Ltd.
NH 74, Moradabad Road, Kashipur (Uttaranchal) 244713 India
Ph- 05947- 275535, 260327, 274338, 277418
Fax- 274338, 275535; Cells- 98 976 18594, 98 976 21896
drrajneeshhom@hotmail.com, drrajneshhom@yahoo.co.in