Arthritis :: Turmeric supplements show promise in treating arthritis

More than 40 percent of arthritis sufferers in the U.S. report using complementary and alternative medicine, including dietary supplements, and the use of alternative remedies has increased since the FDA issued health warnings about anti-inflammatory drugs such as Celebrex. However, the effectiveness of many supplement ingredients has not been adequately studied. To complicate the matter, over-the-counter supplements are not regulated in the same way as drugs and their composition can vary widely. A new study published in the November 2006 issue of Arthritis & Rheumatism examined the effect and mechanism of turmeric (a botanical supplement long thought to have anti-inflammatory properties) on arthritis.

HIV :: Increase in HIV among injecting drug users

A report released by the Health Protection Agency shows that around one in 50 Injecting Drug Users (IDUs) in the UK are now infected with HIV. This is around twice the level seen at the beginning of the decade. In particular the HIV prevalence amongst those injecting for less than three years has increased since 2002. Increasing evidence suggests that crack cocaine is a major factor.

Allergy :: Key enzyme involved in allergic disease identified

A research team has identified a key enzyme responsible for triggering a chain of events that results in allergic reaction, according to new study findings published this week in Nature Immunology. The work by researchers from Virginia Commonwealth University, the Hospital for Special Surgery and Weill Cornell Medical College in New York sets the stage for development of new strategies and target therapies that control allergic disease – the sixth leading cause of chronic disease in the United States.

Hepatitis :: PEG-INTRON, peginterferon and REBETOL, ribavirin in Hepatitis C — Schering-Plough

Schering-Plough reported data from EPIC3, a large ongoing clinical study, showing that retreatment with PEG-INTRON(R) (peginterferon alfa-2b) and REBETOL(R) (ribavirin, USP) combination therapy can result in sustained virologic response(1) (SVR) in patients with chronic hepatitis C who failed previous treatment with any alpha interferon-based combination therapy, including peginterferon regimens. In this study, 56 percent of patients who had undetectable virus (HCV-RNA) after 12 weeks went on to achieve SVR with a 48-week course of therapy. Of the first 1,354 patients retreated, approximately 38 percent had undetectable virus at week 12. Importantly, patients who did not have undetectable virus at 12 weeks had little chance of achieving SVR. Overall, 23 percent of patients achieved SVR.

Cancer :: Saving salivary glands from the collateral damage of radiation therapy

Researchers have shown that targeted overexpression of heat shock protein 25 prevents radiation-induced damage to salivary glands, a common consequence of treatment for head and neck cancer. The related report by Lee et al., “Radioprotective effect of HSP25 on submandibular glands of rats,” appears in the November issue of The American Journal of Pathology.

Hypertension :: Results of TROPHY study on hypertension are misleading

There may be as many as 70 million Americans with prehypertension. If these people can be treated pharmacologically to avoid or delay progression to clinical hypertension, there would be significant benefits to them and the overall health of the population. The recent TROPHY study seems to lead to that conclusion. However, two editorials published in the November issue of the American Journal of Hypertension emphatically argue that the study is flawed and the conclusions reached are misleading.

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