Alzheimer’s Disease :: New alzheimer’s drug shows promise in clinical trial

The only drugs currently available for Alzheimer’s patients are those that alleviate symptoms, but a team of scientists led by Paul Aisen, MD, director of the Memory Disorders program at Georgetown University Medical Center, is testing a new class of drugs that actually target the molecule believed to cause the disease. Aisen and his colleagues report that a compound called tramiprosate reduced levels of a marker for the progression of Alzheimer’s disease in a Phase II clinical trial in the November 1 electronic version of Neurology.

Multiple Sclerosis :: Cure for multiple sclerosis and other myelin-related diseases

A breakthrough finding on the mechanism of myelin formation by Jonah Chan, assistant professor of cell and neurobiology at the Keck School of Medicine of the University of Southern California, could have a major impact on the treatment of diseases such as multiple sclerosis and demyelination as a result of spinal cord injuries.

Lung Transplant :: Proteins may predict lung transplant rejection

Researchers have identified three proteins that appear to be highly predictive of chronic lung rejection up to 20 months before the rejection occurred. Lung transplants are a common therapy for many end-stage lung diseases such as chronic obstructive pulmonary disease, cystic fibrosis and pulmonary hypertension. If doctors can predict which patients are beginning to reject the transplanted organ, they could try to head it off.

Health :: Researchers writing story of the ‘alcoholic lung’

Chronic alcohol abuse disrupts the proteins that keep fluids out of the lung, lowers a protective antioxidant, disrupts immune defenses and can lead to a condition known as “alcoholic lung,” according to research to be presented at the conference, “Physiological Genomics and Proteomics of Lung Disease.” The findings give insight into how excessive drinking can harm the molecular life of the lung and lead to serious illness, including pneumonia and acute respiratory distress syndrome (ARDS.

High Fiber Diet :: High-fiber Diet May Be More Important for Men Than Women

A collaborative effort between the Arizona Cancer Center and the National Cancer Institute (NCI) to understand the influence of diet on recurrence of colorectal adenomas (polyps) a precursor to cancer indicates that a high-fiber diet may be more important for men than women. Although the reason for a sex difference is unknown, researchers suggest that it may be related to hormonal effects or the difference between the sexes in location of polyp formation.

Health :: NCI Researchers Identify Molecular Regulator for Blood Flow in Mice

Researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and Ohio State University, have identified a cellular protein that acts as a regulator for blood flow by blocking blood vessel relaxation induced by nitric oxide (NO). This mouse study appears in the November 2, 2006, online issue of Blood*.

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