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Eyes :: Receptor that enables clear corneas is identified

The cornea stays clear by expressing a soluble form of a receptor that traps factors enabling growth of vision-obstructing blood vessels, researchers say. When sflt-1, a free-floating receptor for vascular endothelial growth factor A, is eliminated, vision-obstructing blood vessels start growing, teams of researchers led by the Medical College of Georgia and University of Kentucky report in Nature. The paper was published online Oct. 18 and will be in the Oct. 26 print issue.

Asthma :: New asthma medicine – Xolair – targeting vulnerable inner-city children

UT Southwestern Medical Center is one of a handful of top research institutions evaluating a promising new medication researchers hope can reduce the severity and frequency of asthma attacks in inner-city children, a population known to have a high prevalence of severe asthma.

Diabetes :: Merck KGaA & Glenmark Pharmaceuticals Collaboration on DPPIV Inhibitor for Type 2 Diabetes

Merck KGaA and Glenmark Pharmaceuticals S.A (Switzerland), a wholly owned subsidiary of Glenmark Pharmaceuticals India (GPL), have entered into an agreement for Glenmark?s DPPIV inhibitor GRC 8200, a treatment for type 2 diabetes in Phase II of clinical development. The transaction is expected to close this year upon approval of the exclusive license to GRC 8200 by the U.S. anti-trust agencies under the HSR Act.

Diabetes :: NovoMix insulin – effective & safe for patients with type 2 diabetes

Data presented at the European Association for the Study of Diabetes (EASD) 42nd Conference in Copenhagen showed NovoMix? 30 (biphasic insulin aspart) to have comparable efficacy to basal-bolus combination therapy, with a similar safety profile in patients previously treated with oral antidiabetic therapy. These findings follow on from the European Commission?s recent decision to approve NovoMix? 30 as the first premixed insulin suitable for once-daily initiation and subsequent intensification of treatment, if needed. The data also confirm the position of NovoMix? 30 as an appropriate treatment choice for patients who prefer a convenient, effective once or twice-daily insulin therapy.

Diabetes :: JANUVIA, sitagliptin phosphate – the First and Only DPP-4 Inhibitor for Type 2 Diabetes

Merck & Co., Inc. announced today that the U.S. Food and Drug Administration (FDA) approved JANUVIA (sitagliptin phosphate), the first and only DPP-4 inhibitor available in the United States for the treatment of type 2 diabetes. JANUVIA has been approved as monotherapy and as add-on therapy to either of two other types of oral diabetes medications, metformin or thiazolidinediones (TZDs), to improve blood sugar (glucose) control in patients with type 2 diabetes when diet and exercise is not enough. The recommended dose of JANUVIA is 100 mg once daily. JANUVIA should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis, as it would not be effective in these settings.

HIV :: Virco introduces an improved rapid methodology to establish new hiv-1 resistance profiles

Responding to the need to make timely evaluations and decisions when treating treatment experienced HIV patients, Virco (http://www.vircolab.com), a leader in drug resistance testing recently introduced an improved virco(R)TYPE HIV-1 test that rapidly determines the complex phenotypic resistance profiles for darunavir, tipranavir and other antiretroviral (ARV) drugs. Utilizing clinical trial data that was used to support the approval of darunavir and tipranavir, virco(R)TYPE HIV-1 reports now include Clinical Cut-Offs (CCOs) for these recently introduced agents(1). Virco(R)TYPE HIV-1 analyzes patient HIV-1 resistant genotypes using Virco’s large database to quickly and accurately predict phenotypic resistance. This timely determination of phenotypic resistance assists physicians in choosing a drug treatment plan that has the least amount of drug resistance.

Pilates :: Top Six Benefits of Pilates Exercises

Pilates is the exercise of choice for dancers, gymnasts, and a host of famous Hollywood celebrities, and now it finds itself firmly entrenched in the mainstream. So why is pilates so hot? Pilates incredible popularity can be traced to the fact that it provides its faithful practitioners with benefits that you simply can’t get through traditional aerobics/strength training format.

Cancer :: Methoxyamine – new cancer therapy reverses resistance to chemotherapy

Case Western Reserve University’s Technology Transfer Office has entered a worldwide exclusive licensing agreement with TRACON Pharmaceuticals of San Diego, Calif., to develop Methoxyamine, a new cancer therapeutic that reverses cancer cell resistance to chemotherapy. Methoxyamine is a “first in class” drug that targets a specific DNA repair pathway.

ADHD :: Preschoolers with ADHD Improve with Low Doses of Medication

The first long-term, large-scale study designed to determine the safety and effectiveness of treating preschoolers who have attention deficit/hyperactivity disorder (ADHD) with methylphenidate (Ritalin) has found that overall, low doses of this medication are effective and safe. However, the study found that children this age are more sensitive than older children to the medication?s side effects and therefore should be closely monitored. The 70-week, six-site study was funded by the National Institutes of Health?s National Institute of Mental Health (NIMH) and was described in several articles in the November 2006 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.

Diabetes :: Plan Will Guide NIH Research in Type 1 Diabetes

The National Institutes of Health (NIH) has released a long range plan that will help to guide research in type 1 diabetes for the next decade. Advances and Emerging Opportunities in Type 1 Diabetes Research: A Strategic Plan identifies goals and objectives to exploit recent scientific advances in combating this autoimmune form of diabetes.