Ankylosing Spondylitis :: Enbrel provides sustained clinical improvements for ankylosing spondylitis for up to 3 years

Amgen (NASDAQ: AMGN) announced patients with ankylosing spondylitis who received treatment with Enbrel (R) (etanercept) experienced sustained improvement in signs and symptoms, spinal mobility and physical function over 148 to 160 weeks of therapy, according to data from an ongoing open-label, multinational, phase 4 extension study presented at the American College of Rheumatology scientific meeting. These results are consistent with an ENBREL phase 3 clinical trial at 24 weeks.

Rheumatoid Arthritis :: Enbrel first biologic with up to 9 years rheumatoid arthritis safety

Amgen (NASDAQ: AMGN) announced Enbrel (R) (etanercept) is the first biologic with published data to show sustained improvements in multiple efficacy measures in rheumatoid arthritis patients completing up to nine years of therapy. Current data suggest Enbrel is both effective and safe in long-term RA use, and the new data, presented at the American College of Rheumatology scientific meeting, provide a degree of reassurance that unexpected safety concerns do not appear to develop after nine years of use.

NYU researchers developing molecular delivery vehicles for genetic therapies

Researchers at New York University are working to develop molecular delivery vehicles that can be used to transport nucleic acids into diverse cell types, which may lead to eventual applications in genetic therapies. Their work is described as part of the cover story in the November 13 issue of the American Chemical Society publication Chemical and Engineering News.

Apnea :: Research questions use of sleep meds for patients with apnea

New research reported in the journal CHEST shows that prescription sleep aids may do little to improve the use of continuous positive airway pressure among patients with obstructive sleep apnea. The study found that patients with OSA who were given prescription sleep aids were no more likely to use their CPAP machines than patients with OSA taking a placebo.

Stem Cell :: Stem cells show promise in repairing heart attack damage

Johns Hopkins scientists have successfully grown large numbers of stem cells taken from adult pigs’ healthy heart tissue and used the cells to repair some of the tissue damage done to those organs by lab-induced heart attacks. Pigs’ hearts closely resemble those in humans, making them a useful model in such research.

Research Findings in Allergy-Immunology Unveiled

Investigators are presenting more than 380 abstracts on preliminary findings in the diagnosis and treatment of allergic diseases at the ACAAI Annual Meeting in Philadelphia, Nov. 9-15. Following are highlights of some key investigations on allergic rhinitis and ocular allergies.

Allergists Explore Rising Prevalence and Unmet Needs Attributed to Allergic Rhinitis

As the prevalence of allergic rhinitis appears to be rising, there are increasing concerns about its impact on health, sleep, work and school performance, as well as unmet patient needs regarding its treatment according to experts presenting new data at the Annual Meeting of the American College of Allergy, Asthma and Immunology (ACAAI).

Research Findings on Allergic Asthma Unveiled

Investigators are presenting more than 380 abstracts on preliminary findings in the diagnosis and treatment of allergic diseases at the ACAAI Annual Meeting in Philadelphia, Nov. 9-15. Following are highlights of some key investigations on allergic asthma.

Genes Offer Researchers a ‘Crystal Ball’ to Help Them Prevent, Diagnose, and Treat Cancer

The science of cancer prevention has advanced to the point where researchers now say they can detect ?cancer genes? in the breath of smokers, and can test the presence of two proteins in men they say will predict development of prostate cancer a decade in advance. All of these novel findings need much more examination, of course, but scientists at the American Association for Cancer Research?s Frontiers in Cancer Prevention Research meeting, say these examples illustrate how it is becoming increasingly possible to use genes and their protein products to help predict and diagnose cancer, as well as choose therapy that offers the most potential for a good result. These researchers will also discuss a test that can pick out patients who have pancreatic cancer – an advance that offers hope the disease can be treated at earlier stages than it is now – and how several unique genes can predict which prostate cancer or lung cancer patients will develop aggressive tumors that need additional treatment. Cancer is a disease of genes, they say, so genes can be employed as a crystal ball to thwart the disease.

Women’s health – Unexpected risk factors found

That women with heart disease generally have worse outcomes than men is well known, but recent research is turning up some unusual and possibly very important new risk factors. Low testosterone levels, ?on-pump? bypass grafts, increased anxiety and under-treatment in secondary prevention may each have an independent, negative impact on women?s outcomes.

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