Researchers at the Jackson Laboratory, in collaboration with scientists at Bristol-Myers Squibb Oncology, discovered is that imatinib does not inactivate all BCR-ABL signaling pathways in the cascade. Proteins called SRC kinases are still activated by BCR-ABL in imatinib-treated mouse leukemic cells. Treatment with dasatinib, which inhibits the SRC proteins as well as BCR-ABL, was not only more effective for CML, but also led to complete B-ALL remission.
Both depression and anxiety disorders worsen the quality of life of asthma patients, report researchers who found that depression also affected patients’ ability to control their symptoms.
A research team at the Consejo Superior de Investigaciones Cient?ficas (CSIC) has discovered a new route for the transport of proteins in plant cells, a discovery that will enable the biotechnological design of plant factories. Amongst other applications, these can be used to produce oral vaccines which, upon being ingested, will be able to immunise against diseases. Moreover, this discovery opens the door to the design of protein-manufacturing plants of great interest therapeutically and in the development of vaccine antigens.
UT Southwestern Medical Center, UT Dallas’ Center for BrainHealth and Shelton School of Dallas will join forces to conduct an innovative three-year research study aimed at helping children with attention deficit hyperactivity disorder and their families.
Current climate change impact models that consider only one weather variable, such as increasing temperature, sometimes spawn unsubstantiated doomsday predictions, according to researchers at Purdue and North Carolina universities.
Researchers at the UCLA Henry Samueli School of Engineering and Applied Science today announced they have developed a new reverse osmosis (RO) membrane that promises to reduce the cost of seawater desalination and wastewater reclamation.
MIT and Cambridge University researchers will unveil the conceptual design for a silent, environmentally friendly passenger plane at a press conference Monday, Nov. 6, at the Royal Aeronautical Society in London.
Magnetic resonance imaging (MRI) could become a valuable tool for predicting the risk of muscle injury during and following radiation therapy, according to investigators at St. Jude Children’s Research Hospital.
Biologists have learned where and how some plant seeds store iron, a valuable discovery for scientists working to improve the iron content of plants. Their research helps address the worldwide problem of iron deficiency and malnutrition in humans.
Rhinoceros horns have long been objects of mythological beliefs. Some cultures prize them for their supposed magical or medicinal qualities. Others have used them as dagger handles or good luck charms. But new research at Ohio University removes some of the mystique by explaining how the horn gets its distinctive curve and sharply pointed tip.