Tamiflu linked to abnormal behavior

The maker of the antiviral medication Tamiflu issued a new warning for the flu drug Monday, saying patients must be closely monitored for potential psychiatric problems, including delirium and suicide.

Hoffman-La Roche Inc. had been discussing the matter with the Food and Drug Administration, which has been reviewing 103 cases in which patients reported bizarre behavior, usually within a day of taking Tamiflu.

Tamiflu or Oseltamivir (INN) (IPA: [ɒsɛlˈt?mɪvir]) is an antiviral drug that is used in the treatment and prophylaxis of both Influenzavirus A and Influenzavirus B. Like zanamivir, oseltamivir is a neuraminidase inhibitor. It acts as a transition-state analogue inhibitor of influenza neuraminidase, preventing new viruses from emerging from infected cells.

Oseltamivir was the first orally active neuraminidase inhibitor commercially developed. It is a prodrug, which is hydrolysed hepatically to the active metabolite, the free carboxylate of oseltamivir (GS4071). It was developed by Gilead Sciences and is currently marketed by Hoffmann-La Roche (Roche) under the trade name Tamiflu. It is generally available by prescription only.

With increasing fears about the potential for a new influenza pandemic, oseltamivir has received substantial media attention. Production capacity is limited, and governments (and even some private individuals) are stockpiling the drug.


Tamiflu linked to abnormal behavior
by ( Author at Spirit India )
Posted on at 8:45 pm.
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