Stent :: Safety of carotid stenting in ‘real-world’ setting

The largest-ever study of carotid stenting in high-surgical risk patients has shown that with proper education and training, community physicians are just as successful at using catheter-based techniques to unclog arteries supplying blood to the brain as are those who pioneered the procedure at major university medical centers.

Nanotechnology :: Future of nanotechnology discussed by experts

Many people believe nanotechnology will be the key to solving many of the world’s most pressing medical problems, while others believe it could lead to a potential disaster. The current issue of the Journal of Law, Medicine & Ethics addresses this issue in all its aspects.

Breast Cancer :: Tykerb, lapatinib – novel breast cancer drug

A clinical trial of a new targeted breast cancer drug, led by physicians at Massachusetts General Hospital (MGH) Cancer Center, has begun enrolling patients. The TEACH (Tykerb Evaluation After CHemotherapy) trial will investigate the experimental drug Tykerb (lapatinib) in patients with early-stage, HER2-positive breast cancer who have not been treated with Herceptin, another targeted drug used for the same type of tumor.

Botulinum :: Seeing a neurotoxin’s deadly grip

Two Howard Hughes Medical Institute (HHMI) research teams working independently have discovered new information about how the botulinum neurotoxin shuts down neurons with deadly efficiency. By providing detailed views of the toxin plugged into its neuronal receptor, the new studies could aid efforts to engineer specialized versions of the powerful neurotoxin that is used to treat a wide array of medical problems.

Botulinum :: How botulinum toxin attaches to nerve cells – explained

A group of researchers, funded in part through two of NIAID’s Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases, has provided a rare atomic glimpse of the initial step one of botulinu’s toxins takes to gain entry into human neurons. In an advanced online publication of the journal Nature, the scientists show structurally how botulinum neurotoxin B (one of seven toxins the bacterium produces) recognizes receptors on the surface of human neurons.

RNA :: Hairpins for switches

How does an organism know when it must produce a protein and in what amount? Clever control mechanisms are responsible for the regulation of protein biosynthesis. One such type of mechanism, discovered only a few years ago, is riboswitches, which function as a sort of “off” switch for the production of certain proteins.

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