Schizophrenia :: How schizophrenia develops, major clues discovered

Schizophrenia may occur, in part, because of a problem in an intermittent on/off switch for a gene involved in making a key chemical messenger in the brain, scientists have found in a study of human brain tissue. The researchers found that the gene is turned on at increasingly high rates during normal development of the prefrontal cortex, the part of the brain involved in higher functions like thinking and decision-making — but that this normal increase may not occur in people with schizophrenia.

Cancer :: CD8+ T cells LAG behind

New data generated using mice by Charles Drake and colleagues at Johns Hopkins University School of Medicine, Baltimore, have identified a role for the protein LAG-3 in limiting the response of immune cells known as CD8+ T cells to both host and tumor proteins.

Immunity :: The ins and outs of how neutrophils combat microbes

Immune cells known as neutrophils produce reactive oxygen intermediates (ROIs) to combat infection with microbes that can cause diseases such as pneumonia. New insight into the molecular pathway regulating neutrophil production of ROIs in mice has been provided by Wojciech Swat and colleagues at Washington University School of Medicine, St. Louis.

Colorectal Cancer :: Racial and ethnic differences in colorectal cancer emphasize importance of screening

New research presented at the 72nd Annual Scientific Meeting of the American College of Gastroenterology emphasizes the importance of colorectal cancer (CRC) screening among racial and ethnic minorities, who have a higher incidence of colorectal cancer compared to Caucasians. Two studies found more African-Americans had advanced polyps on the right side of the colon than Caucasians, while results from colonoscopy screenings of Latin Americans revealed similarly high risk findings to African-Americans.

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