Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in the development of new diagnostic tests and cancer medications.
One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers.
Through the generous philanthropic support of the Littlefield 2000 Trust, the American Association for Cancer Research is pleased to announce four recipients of the 2007 Jeannik M. Littlefield-AACR Grants for Metastatic Colon Cancer Research, totaling $2.7 million. Now in its second year, this competitive grant program supports the cutting-edge research of top scientists from around the world, working to accelerate the discovery and development of new treatments for metastatic colon cancer.
Women who overcome breast cancer have every reason to celebrate. But a heart filled with joy may also be a heart damaged by life-saving cancer therapies, a growing body of research shows.
Men who have prostate cancer are on average four times more likely to suffer a hip fracture, with rates rising to eight times in men aged 50 to 65, according to a study of more than 60,000 men published in the October issue of the urology journal BJU International. Danish researchers looked at 62,865 men aged 50 and over, with an average age of just under 67.
In rats with portal hypertension, ultra¨Clow-dose aspirin has shown a normalizing effect of platelet-endothelial cell alterations and bleeding time. Further, this effect is mediated by Cyclooxygenase 2 inhibition.
MIT researchers have discovered a link between a gene believed to promote long lifespan and a pathway that flushes cholesterol from the body. The finding could help researchers create drugs that lower the risk of diseases associated with high cholesterol, including atherosclerosis (clogged arteries) and Alzheimer’s disease.
The Bill & Melinda Gates Foundation announced that it is committing $100 million over five years to create a new fast-track grants initiative to support innovative global health research.
A fascinating new study is the first outside of North America to observe lower testosterone levels among married men. Supporting a growing body of research, the study reveals that even married men who are considered aloof spouses and provide minimal parenting have much lower testosterone levels than single, unmarried men.
Members of the Nonprescription Drug Manufacturers Association of Canada announced the voluntary withdrawal of oral cough and cold medicines intended for use in children under the age of two years. The withdrawal is a highly cautionary response to rare patterns of misuse identified during the course of a review of safety data related to children’s cough and cold medicines.