Diabetes :: Linchpin discovered in insulin metabolism

Scientists at the University of Bonn have identified a new gene which could play an important role in the development of diabetes. Flies in which this hereditary factor is defective are also significantly smaller than other members of their species and live appreciably longer. In the current issue of the prestigious journal Nature the Bonn researchers have published two articles on this topic.

Breast Cancer :: Efficacy of Pfizer’s Aromasin for early breast cancer

New data from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-33 study, presented today at the San Antonio Breast Cancer Symposium, showed that postmenopausal women with hormone receptor-positive breast cancer who received Aromasin after five years of tamoxifen were 56 percent less likely to have a relapse of breast cancer than those who received placebo.

Cancer :: How NSAIDs halt cancer growth explained

Scientists have discovered that induction of a gene known as MDA-7/IL-24 is the molecular mechanism that enables nonsteroidal anti-inflammatory drugs (NSAIDs) to halt the growth of cancer cells, a finding that could eventually lead to the development of targeted cancer treatments.

Botulism :: Molecular basis of botulism toxin’s deadly activity

Scientists at the Scripps Research Institute, the University of Wisconsin School of Medicine and Public Health, and the Howard Hughes Medical Institute have revealed in atomic detail how the toxins that cause botulism target and bind to nerve cells. This new understanding could ultimately lead to new ways for treating botulism, as well as to improved therapies for nervous system diseases such as dystonias, cerebral palsy and multiple sclerosis.

Taking nanolithography beyond semiconductors

A new process for chemical patterning combines molecular self-assembly with traditional lithography to create multifunctional surfaces in precise patterns at the molecular level. The process allows scientists to create surfaces with varied chemical functionalities and promises to extend lithography to applications beyond traditional semiconductors.

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