West Nile Virus :: Humans MIFfed by West Nile Virus

Infection with West Nile Virus (WNV) can cause lethal encephalitis and there are currently no vaccines or specific therapeutics for use in humans. However, data generated by Erol Fikrig and colleagues at Yale University School of Medicine has provided evidence that the proinflammatory soluble factor MIF might provide a target for developing therapeutics to treat WNV encephalitis.

Smoking :: New study reveals mechanism behind nicotine dependency

The new study reveals that, in rats, chronic nicotine use recruits a major brain stress system, the extrahypothalamic corticotropin releasing factor (CRF) system, which contributes to continued tobacco use by exacerbating anxiety and craving upon withdrawal. The researchers found that administering a compound that blocked the receptors involved in this stress system alleviated withdrawal symptoms.

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