Heart Disease :: MEDAL – No increase in cardiovascular events with COX-2 inhibitor

Researchers in the randomized Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) study program found identical rates of thrombotic cardiovascular events in patients with osteoarthritis or rheumatoid arthritis treated with either the COX-2 inhibitor or the traditional NSAID. Christopher Cannon, M.D., an associate professor of medicine at Harvard Medical School, Boston, noted that this appears to contradict earlier observational studies associating COX-2 inhibitors with higher rates of thrombotic cardiovascular events.

Heart Disease :: Stent wars ease into stent discussions

Acrimonious debate over the use of bare metal stents (BMS) versus drug-eluting stents (DES) is ending. Four new studies presented during a Monday news conference are quickly turning what had been open warfare between BMS and DES advocates into more measured discussions.

Heart Disease :: Anticoagulant-antidote combo safe in humans

A novel anticoagulant and its complementary antidote was proven safe in the first human trial, say researchers from Duke University Medical Center, Durham, N.C. The system could be valuable, holding promise that clinicians could titrate anticoagulation, as it may not require monitoring.

Heart Disease :: PCI for occlusion after MI not always beneficial

Logic would hold that an occluded infarct-related artery should be open before the patient is discharged. But the chair of the Occluded Artery Trial (OAT) presented data here showing that stable patients undergoing routine PCI for occluded arteries three to 28 days after MI had virtually the same number of major cardiovascular events as similar patients receiving medication alone.

Septic Shock :: New study finds on/off switch for septic shock

According to a new study, septic shock — a dangerous, often deadly runaway immune response — is controlled by a genetic on/off switch. The research also suggests how a drug might temper sepsis. This is the first time this genetic mechanism has been revealed in an experimental animal.

HIV :: No link found between erectile medications and HIV

Erectile dysfunction (ED) medications known as Phosphodiesterase type 5 (PDE-5) inhibitors have been used by millions of men as safe and effective management options associated with high rates of patient and partner satisfaction.

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