Gene :: Genetic mutation alters response to heart failure drugs

Drugs known as beta blockers help reduce the heart’s workload during heart failure via their action on beta-adrenergic receptors in cardiac cells. However, doctors remain puzzled by the variable responses to beta blockers among patients. Researchers now show that the key to this variation lies in a single amino acid change in the beta1-adrenergic receptor, that may differ from person to person, which alters the receptor’s conformation and the receptor’s response to certain beta blockers.

Brain :: How appetite-stimulating brain cells work overtime during fasting

During periods of fasting, brain cells responsible for stimulating the appetite make sure that you stay hungry. Now, a new study of mice reported in the January issue of the journal Cell Metabolism, published by Cell Press, reveals the complex series of molecular events that keep those neurons active.

Imaging :: Imaging pinpoints brain regions that ‘see the future’

Using brain imaging, researchers from Washington University in St. Louis have identified several brain regions that are involved in the uniquely human ability to envision future events. The study, to be published in the journal PNAS, provides evidence that memory and future thought are highly interrelated and helps explain why future thought may be impossible without memories. Findings suggest that envisioning the future may be a critical prerequisite for many higher-level planning processes.

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