q Lupus :: Over one-third of refractory lupus patients remain stable at long term follow-up | Health | Spirit India

Lupus :: Over one-third of refractory lupus patients remain stable at long term follow-up

Thirty-six percent of patients with refractory systemic lupus erythematosus remain well after undergoing B-cell depletion therapy without needing further standard immunosuppressive agents, according to a study presented today at EULAR 2007, the Annual European Congress of Rheumatology in Barcelona, Spain.

Overactive B-cells are commonly found in patients with SLE and reducing the number of B-cells in the system by BCDT has been suggested as a promising therapy for SLE patients who are unresponsive to other treatments.

In this study, initiated in 2000, patients with refractory SLE were treated with BCDT (based on rituximab) using a combination protocol with cyclophosphamide and steroids. Of the 33 patients who had a minimum of 6 months follow-up duration at the time of analysis (mean duration 37 months, range 6-79), 12 patients remained well. Median duration of B-cell depletion was 4 months (range 2-15), with 2 patients remaining depleted at time of analysis (73 and 8 months respectively). B-cell depletion was beneficial clinically, with a decrease of median global BILAG scores (clinical activity index ? see Editors note) from 13 to 5 when measured between 5 and 8 months p


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