Fever :: Children under stress develop more fevers

Children whose parents and families are under ongoing stress have more fevers with illness than other children. Published this month in the Archives of Pediatric and Adolescent Medicine, the study also shows the unanticipated conclusion that children’s natural killer cell function, part of the body’s innate immune system, increases under chronic stress, unlike adults, whose function is decreased.

Pediatrics :: Most children in US hospitals receive medicines off-label

Nearly four out of five hospitalized children receive medications that have been tested and approved only for adults, according to a study of hundreds of thousands of patient records. This so-called “off-label” use of drugs was thought to be especially common in children, and the new research, the largest-ever U.S. pediatric study, confirms this.

Osteoporosis :: Protein regulates bone mass loss, the cause of osteoporosis

An estimated ten million Americans suffer from osteoporosis, and another 34 million Americans are at risk of developing the disease, which is characterized by a severe loss of bone mineral density, fragile bones and an increased risk of hip, spine and wrist fractures. The basic mechanism behind osteoporosis involves an imbalance between bone mineral formation and loss, but the detailed biological processes that lead to this imbalance are not completely understood.

HIV :: Risk of HIV transmission highest early in infection

New evidence suggests that the risk of HIV transmission may be highest in the early stages of infection. According to a study published in the April 1 issue of the Journal of Infectious Diseases, now available online, early infection accounted for nearly half of all transmission occurrences in an HIV-infected population in the province of Quebec, Canada.

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