Compounds known to play an important role in how insects develop from larvae to adults have been shown in a mouse model for congestive heart failure to be effective in preventing and reducing cardiac cell overgrowth and irregular heart rhythms, according to UC Davis research published in the early online edition of the Proceedings of the National Academy of Sciences.
An enzyme inhibitor that regulates insect larvae development reduces heart enlargement and irregular heart rhythms in a mouse model, a 16-member University of California, Davis research team has discovered. The work, published in the current edition of Proceedings of the National Academy of Sciences, could lead to important new medications to treat human heart patients.
Using advanced new microscopy techniques in concert with sophisticated transgenic technologies, scientists at The Wistar Institute have for the first time created three-dimensional, time-lapse movies showing immune cells targeting cancer cells in live tumor tissues. In recorded experiments, immune cells called T cells can be seen actively migrating though tissues, making direct contact with tumor cells, and killing them.
Researchers at the Stanford University School of Medicine discovered that when a molecule responsible for dialing down the immune system malfunctions in the brain cells of mice, the rodents develop symptoms of the degenerative brain disease.
Hearty feasts and couch-potato marathons are holiday traditions, but UT Southwestern Medical Center experts warn that packing on pounds and not exercising could be deadly for the 6 million Americans who have diabetes and don’t even know it.
New research at Wake Forest University School of Medicine suggests that certain inhaled asthma medications ? as well as similar chemicals our bodies produce during times of high stress ? may worsen diseases such as asthma, heart failure and lupus that involve inflammation.
The dynamics of evolution are fully in play within the environment of a tumor, just as they are in forests and meadows, oceans and streams. This is the view of researchers in an emerging cross-disciplinary field that brings the thinking of ecologists and evolutionary biologists to bear on cancer biology.
Cells in the outermost layer of the heart can be guided by a specific protein to move deeper inside and help to repair a failing adult heart. Research published today by Nature, reveals how thymosin ?4, a protein already known for its ability to reduce muscle cell loss after heart attack, can instruct the heart to heal itself.
New research at Wake Forest University School of Medicine suggests that certain inhaled asthma medications — as well as similar chemicals our bodies produce during times of high stress — may worsen diseases such as asthma, heart failure and lupus that involve inflammation.
Research led by King’s scientists, and published online in the journal Nature, sheds new light on the development of the immune cells which are critical in fighting infection and some tumours. It may also provide clues to the mystery of why autoimmune diseases in women often go into remission during pregnancy.