Pfizer said today that the Austrian Patent Office has ruled that a claim in the company’s basic patent covering the use of atorvastatin, the active ingredient in Lipitor, would be infringed by generic manufacturer Ranbaxy. Ranbaxy can appeal the ruling, but the patent will remain in effect during the appeals process. Lipitor is sold in Austria under the brand name Sortis.
Roche and InterMune Inc. announced that the companies have entered into an exclusive worldwide collaboration agreement to develop and commercialize products from InterMune?s Hepatitis C (HCV) protease inhibitor program. The agreement includes InterMune?s lead candidate compound ITMN-191, expected to enter clinical trials before the end of the year. The companies will also collaborate on a research program to identify, develop and commercialize novel second-generation HCV protease inhibitors.
New data released today demonstrate significantly better immune responses in the age range 65 and above when vaccinated with GSK?s new generation (adjuvanted) seasonal flu vaccine compared to a traditional seasonal flu vaccine. These new data are highly important, since the disease burden and death toll is highest among the elderly in each flu season. The data, presented at the Influenza Vaccines for the World (IVW) 2006 Congress, showed the seroprotection rate (90.5%) achieved by the new adjuvanted vaccine in the elderly to be more than 25% higher than that reported in the age matched comparator group.
GlaxoSmithKline (plc) today announced that a supply contract has been signed by the Swiss Federal Office of Public Health and GlaxoSmithKline for 8 million doses of GSK?s H5N1 antigen influenza vaccine and its proprietary adjuvant for pre-pandemic use. The order provides enough doses, one per head of the entire Swiss population, to help prepare the immune system against the threat of a human influenza pandemic and is the first national programme to do so. Supply and stockpiling of the pre-pandemic vaccine is expected in early 2007 once the Swiss regulatory agency, Swissmedic, has reviewed and approved GSK?s regulatory file.
Bayer HealthCare (NYSE: BAY) and Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN) today announced that the companies have entered into a collaboration agreement for the global development, and commercialization outside the U.S., of the VEGF Trap for the treatment of eye disease by local administration (VEGF Trap-Eye). The VEGF Trap-Eye, currently in Phase I and Phase II clinical trials, is a protein that binds to or ?traps? vascular endothelial growth factor (VEGF) and blocks its activity. VEGF is thought to play a critical role in certain eye diseases.
A child?s susceptibility to autism is increased with a single gene mutation according to research conducted by, a Vanderbilt-led research team. This discovery has far-reaching implications because this gene, a variant form of a gene called MET, is not just specifically a brain gene but rather a gene which has its effect on multiple systems in the body such as immune function and gut repair.
US scientists have come up with a new way to determine whether someone is suffering from an eating disorder – examining their hair. A study released by researchers from Utah’s Brigham Young University found that examining carbon and nitrogen in the proteins of hair could reveal information about a person’s day-to-day nutrition.
The anthrax vaccine, used to combat bio-warfare, is to be restarted with a mandatory immunisation program for troops in Afghanistan, Iraq and South Korea, declared the Pentagon. However it is not planning to do the same for troops serving in other places including the US.
At the 11th biennial meeting of the International Gynecologic Cancer Society (IGCS) underway in Santa Monica, CA, the potential impact of widespread adoption of HPV vaccination among girls in Mexico was described. In a study, “HPV-Vaccination Impact on Cervical Cancer Incidence and Mortality in Mexico: A Cancer Registry Based Model,” a team from the Mexican Institute of Social Security (Instituto Mexicano Del Seguro Social), the Mexican Institute of Public Health (Instituto Nacional de Salud Publica) and GlaxoSmithKline (GSK) concluded that HPV vaccination targeting HPV subtypes 16 and 18 could reduce cervical cancer cases and deaths by 60 percent.
Researchers in the Greene Infectious Disease Laboratory at Columbia University’s Mailman School of Public Health, the Centers for Disease Control and Prevention, and the Caribbean Primate Research Center have discovered a key mechanism by which the Filoviruses, Ebola and Marburg, cause disease. The identification of an amino acid sequence in Filoviruses that results in the rapid depression of immunological response is described in the December 2006 issue of The FASEB Journal. Using this information, researchers can begin to develop new drugs to stop these devastating diseases.