HIV :: p21 stops HIV-1 in its tracks in hematopoietic stem cells

Hematopoietic stem cells (HSCs) are one of the few cell types able to resist infection with HIV-1 despite expressing the cell surface molecules to which HIV-1 binds before entering a cell. In a study that appears in the February issue of the Journal of Clinical Investigation, researchers from Harvard Medical School, Boston, show that HSC expression of a protein known as p21Waf1/Cip1/Sdi1 (p21) is required for HSCs to be resistant to infection with HIV-1.

HIV :: Phase III trials of cellulose sulfate microbicide for HIV prevention closed

CONRAD, a reproductive health research organization, announced today that it has halted a Phase III clinical trial of cellulose sulfate — a topical microbicide gel being tested for HIV prevention in women — because preliminary results indicated that cellulose sulfate could lead to an increased risk of HIV infection in women who use the compound.

HIV :: HIV Dementia alarmingly high in Africa

An international study led by Johns Hopkins suggests that the rate of HIV-associated dementia is so high in sub-Saharan Africa that HIV dementia along with Alzheimer?s disease and dementia from strokes may be among the most common forms of dementia in the world.

HIV :: Australia plans $10m HIV campaign

The number of HIV infections in Australia increased by 41 per cent between 2000 and 2005, and the Australian government is considering A$10 million safe sex campaign to combat a surge in HIV infections.

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