Cancer :: Agennix receives fda orphan drug designation for talactoferrin alfa in renal cell carcinoma

Agennix today announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation to the Company’s oral formulation of Talactoferrin Alfa (talactoferrin or TLF) for the treatment of renal cell carcinoma (RCC). Oral TLF is currently in Phase II clinical development for RCC. Results from a multi-center Phase 2 RCC trial that included six leading U.S. cancer centers were presented at the 2006 Annual meeting of the American Society of Clinical Oncology (ASCO).

Cancer :: Agencourt genomic services is key collaborator in new study on breast and colon cancer genes

Agencourt Bioscience Corporation, a Beckman Coulter company, has announced that its Genomic Services were integral in a breakthrough Johns Hopkins study on the genetic code for breast and colon cancers. A recent and widely publicized report on that study, published this month in Science Express, was co-authored by James Hartigan, an Agencourt project manager. The research identifies close to 200 mutated genes, now linked to these cancers, most of which were not previously recognized as associated with tumor initiation, growth, spread or control. The study provides an understanding into disease processes and is expected to drive cancer research for years to come.

Breast Cancer :: Breast cancer risk dependent upon ethnic variations in hormone levels

Researchers have known that a woman’s natural hormone levels can affect her risk of developing breast cancer. A new study from the University of Southern California (USC) has found that the natural levels of estrogens in post-menopausal women varies by ethnicity and race, and may explain the differences in the groups’ breast cancer rates. The study appears in the October issue of Cancer Epidemiology, Biomarkers & Prevention.

Lung Cancer :: Lung cancer may be hereditary, study shows

People who have a family history of lung cancer are at nearly double the risk of developing the disease themselves, according to new research. In a large-scale, population-based cohort, Japanese researchers studied the association between family history of lung cancer and subsequent risk.

Breast Cancer :: Risk of anemia reduced by exercise in breast cancer patients

Women undergoing radiation treatment for breast cancer benefit from moderate intensity, regular aerobic activity, according to a new study. Published in the November 15, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study found that exercise improved the oxygen capacity of patients and maintained levels of red blood cells during radiation treatment. In contrast, women who did not exercise experienced significant declines in their oxygen capacity. This is the first study to investigate the effect of exercise during treatment.

Prostate Cancer :: Obesity independently impacts prostate cancer screening

When interpreting prostate cancer screening test results, physicians should consider the impact of a patient’s body mass index, regardless of race, according to a new study. Published in the November 15, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study found that obese African-American and Caucasian men had lower levels of prostate surface antigen (PSA) and free PSA (fPSA) than men with normal body mass index (BMI), suggesting that an obese man with a slightly elevated PSA may be at higher risk for prostate cancer than a man with normal BMI.

Cancer :: The leukemia & lymphoma society launches program to ease the return to school for children with cancer

Each year approximately 9,000 children and teenagers are diagnosed with cancer in the United States, with leukemia representing more than 30% of these cases. Thanks to research advances, the survival rate for the most common pediatric cancer, acute lymphocytic leukemia (ALL), has improved from a dismal 4 percent in the 1960s to more than 85 percent today. However, for children who survive cancer, the challenges continue long after the treatments are over.

Breast Cancer :: Critical gaps in breast cancer patient education and communication

Results from a recent survey of European women with early breast cancer, presented for the first time at the European Society for Medical Oncology (ESMO) congress, show that the information needs of patients are not being met and that there is an unacceptably low level of patient involvement in potentially life-extending treatment decisions. The survey revealed that older women, those with a low level of education and those without Internet access are particularly uninformed.

Breast Cancer :: Genetic alterations may explain racial disparity in breast cancer

Molecular and genetic alterations that cause tumors and drive the course of disease may someday explain the differences in incidence and mortality between African American and European American breast cancer patients. This is the conclusion of a literature review by a research team at Roswell Park Cancer Institute (RPCI) led by Christine B. Ambrosone, PhD, Chair of Epidemiology at RPCI. Results of the study are published in the September edition of Cancer Research.

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