Breast Cancer :: Breast cancer survival rates improved by novel drug sequence

Changing the way women are treated for breast cancer could improve their overall chance of survival, according to research published today in the Lancet. The new paper shows that switching to a drug called exemestane, two to three years after commencing standard therapy with the drug tamoxifen, can cut the risk of death for certain women by a further 17 percent compared with using tamoxifen alone.

Lung Cancer :: Modeling lung cancer

In a new report in the February 15th issue of G&D, Dr. Martin McMahon (UCSF) and colleagues present a novel mouse model of non-small cell lung cancer, which will serve as a useful tool to test the efficacy of novel chemotherapeutic drug therapies in the early stages of lung tumorigenesis.

Cancer :: Oxidative stress stimulates p38 MAPK-mediated tumor suppression

A new study finds that p38-alpha MAPK can sense oxidative stress in cells and respond by inhibiting tumor formation. The research, published in the February issue of the journal Cancer Cell, published by Cell Press, provides exciting new insight into the specific mechanisms by which ? suppresses the development of cancer and identifies possible targets for development of new anticancer therapeutics.

Cancer :: Screening tumors’genetic profile for cancer treatment

A study led by researchers at Dana-Farber Cancer Institute and Broad Institute of the Massachusetts Institute of Technology and Harvard University provides the first demonstration of a practical method of screening tumors for cancer-related gene abnormalities that might be treated with “targeted” drugs.

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