Theory of oscillations may explain biological mysteries

An article by John Vandermeer of the University of Michigan shows how extensions of established theory can model coupled oscillations resulting from interactions such as predation and competition. Such coupling can have far-reaching effects that may explain the higher-than-expected diversity of plankton in aquatic ecosystems and other paradoxes of species distribution.

Breast Cancer :: Abortion pill Mifeprex, RU-486 blocks breast cancer

Cell biologist Eva Lee of the University of California, Irvine, who led the research published in Friday’s edition of the journal Science, reported that a pill that women can take to abort a fetus, has the ability to put a strangle hold on the gene primarily responsible for breast cancer. The drug is called RU-486, and when given to genetically developed mice who were destined to develop breast cancer, proved to halt the progression of the disease.

Heart Disease :: Barr’s Subsidiary PLIVA Receives Approval for Pravastatin Tablets

Barr Pharmaceuticals, Inc. (NYSE: BRL) and its subsidiary PLIVA d.d. (LSE: PLVD; ZSE: PLVA-R-A) today announced that PLIVA has received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) to manufacture and market Pravastatin Tablets 10mg, 20mg, and 40mg, the generic version of Bristol-Myers Squibb’s PRAVACHOL(R) (Pravastatin Sodium) Tablets. The Company plans to launch its product immediately. PLIVA has also received tentative approval for its Pravastatin Tablets 80mg strength and plans to launch this strength following the expiration of a competitor’s 180-day generic drug exclusivity period and subsequent final approval of PLIVA’s application.

Embolism :: Oral anticoagulant rivaroxaban shows efficacy and safety for prevention of VTE

Phase II clinical trial results published today in Circulation (2006;114:2374-2381) highlight the potential of a simple, once-daily dosing regimen of the novel, oral anticoagulant rivaroxaban (BAY 59-7939), a direct Factor Xa inhibitor. In this trial, rivaroxaban demonstrated that it may have similar safety and efficacy to subcutaneous enoxaparin (the current standard), for the prevention of venous thromboembolism (VTE) in patients undergoing elective total hip replacement surgery.

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