Cancer :: Genetically modified cells attack tumors

Mice with neuroblastoma tumors have been successfully treated with genetically modified cells that sought out the cancer cells and activated a chemotherapy drug directly at those sites, according to investigators at St. Jude Children’s Research Hospital and their colleagues at City of Hope National Medical Center (Duarte, Calif.) and the University of British Columbia (Vancouver, Canada). Neuroblastoma is a solid tumor that arises in the part of the nervous system outside the brain.

Gene :: Human and chimp genes 6% unique

Approximately six per cent of human and chimp genes are unique to those species, report scientists from the University of Bristol and three other institutions.

Aging :: Exercise enhances seniors’ physical, mental functioning

For older Americans, reversal of the brain shrinkage that occurs as people age is just one benefit of greater physical activity, according to research published in the latest issue of the Journal of Gerontology — Medical Sciences (Vol. 61A, No. 11). In a special section devoted to exercising and aging, this edition of the journal features five separate reports on the topic.

Schizophrenia :: Schizophrenia’s protein biomarkers found in body tissue

A new study suggests biochemical changes associated with schizophrenia aren’t limited to the central nervous system and that the disease could have more encompassing effects throughout the body than previously thought. The findings, scheduled for publication in the next issue of the American Chemical Society’s Journal of Proteome Research, could lead to better diagnostic testing for the disease and help explain why those afflicted with it are more prone to other chronic health problems.

Urinary Tract Infection :: Treatments for urinary infections leave bacteria bald, happy and vulnerable

A different approach to treating urinary tract infections (UTIs) could defeat the bacteria that cause the infections without directly killing them, a strategy that could help slow the growth of antibiotic-resistant infections. Researchers at Washington University School of Medicine in St. Louis have been working to create pharmaceuticals that essentially “defang” the bacteria by preventing them from assembling pili, microscopic hairs that enable the bacteria to invade host cells.

Alzheimer’s Disease :: Testosterone therapy prevents Alzheimer’s disease

Researchers at the University of Southern California have discovered a direct link between loss of testosterone and the development of an Alzheimer’s-like disease in mice. They also discovered that testosterone treatment slows progression of the disease.The study, published in the Dec. 20 issue of the Journal of Neuroscience, predicts that testosterone-based hormone therapy may be useful in the treatment and prevention of Alzheimer?s disease in aging men.

Vitamin D :: Vitamin D lowers multiple sclerosis risk

New research suggests that having higher circulating levels of vitamin D is associated with a reduced risk for multiple sclerosis, although this relationship was not seen for black and Hispanic individuals, according to a study in the Dec. 20 issue of JAMA.

Kidney Stones :: Kidney stones and nanoparticles

Researchers at Mayo Clinic have successfully isolated nanoparticles from human kidney stones in cell cultures and have isolated proteins, RNA and DNA that appear to be associated with nanoparticles.

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