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Multiple Sclerosis :: Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease

An immune system messenger molecule that normally helps quiet inflammation could be an effective tool against multiple sclerosis (MS). Neurology researchers led by Abdolmohamad Rostami, M.D., Ph.D., professor and chair of the Department of Neurology at Jefferson Medical College of Thomas Jefferson University and the Jefferson Hospital for Neuroscience in Philadelphia, have found that the protein interkeukin-27 (IL-27) helped block the onset or reverse symptoms in animals with an MS-like disease.

Lupus :: Research suggests targeted treatment strategies for lupus

New research provides clues about the causes of lupus symptoms and suggests specific new targeted treatment strategies, according to Nilamadham Mishra, M.D., from Wake Forest University Baptist Medical Center, in presentations this week at the American College of Rheumatology in Boston.

Lupus :: Existing drugs show promise for treating end-stage renal disease in lupus

Studies in mice suggest that two drugs already approved by the U.S. Food and Drug Administration show promise for treating the complications of lupus, according to Nilamadham Mishra, M.D., in presentations this week at the American College of Rheumatology in Boston.

Heart :: Aging heart changes shape, shrinks and loses pumping function too

Researchers at Johns Hopkins have evidence to explain why the supposedly natural act of aging is by itself a very potent risk factor for life-threatening heart failure.

Colorectal Cancer :: Curry-derived molecules might be too spicy for colorectal cancers

Curcumin, the yellowish component of turmeric that gives curry its flavor, has long been noted for its potential anti-cancer properties. Researchers from Tohoku University in Sendai, Japan, report on an apparent improvement upon nature: two molecular analogues of curcumin that demonstrate even greater tumor suppressive properties.

HIV :: A hairpin to fight HIV

When a host cell is infected with HIV, the virus brings its own genetic material into the host cell. This cell then replicates, reads the viral RNA, and uses it as a blueprint to produce more viral proteins. Complete viruses are then released to attack the next cells.

Drug :: How does the antitumor drug get to the cell nucleus?

Platinum complexes such as the well-known cisplatin are powerful antitumor medications. They cross the cell membrane and reach the nucleus, where they attach to DNA and stop cell growth. But how does cisplatin get to the nucleus? Italian researchers have now proven that a copper transport protein may play a critical role. In the journal Angewandte Chemie, they present their hypothesis about the transport mechanism.

HIV :: HIV-TB spreads in Africa, undermines control of world’s 2 deadliest infectious diseases

The largely unnoticed collision of the global epidemics of HIV and tuberculosis (TB) has exploded to create a deadly co-epidemic that is rapidly spreading in sub-Saharan Africa. However, health systems cannot adequately diagnose, treat, or contain the co-epidemic due to unanswered scientific and medical questions, according to a report issued today by The Forum for Collaborative HIV Research and amplified by experts from leading global health organizations.

Food :: Consumer demand flavors food import safety issues

An ever-changing U.S. consumer who enjoys the convenience of ready-to-eat produce and seasonable fruits during the dead of winter has brought new challenges to food import safety, experts said Oct. 18. With U.S. food imports set to top more than $2 trillion this year and expected to triple by 2015, a panel on food safety commissioned by President Bush met at Texas A&M University to discuss ways to strengthen the national and global import infrastructure.

Obesity :: Fighting obesity may be as easy as ATP, says UH researcher

Wearing a portable instrument to monitor metabolism in the fight against obesity and its related health consequences may be on the horizon thanks to collaborative research being performed at the University of Houston and The Methodist Hospital.