Drug :: Microenvironment of Tumors Plays Role in Drug Resistance

The difficulty in penetrating tumors and reaching all of the cancer cells is an important but under-appreciated cause of drug resistance in solid tumors, according to a review article.

Olivier Trédan, M.D., of the University of Toronto and colleagues describe how the tumor microenvironment may be involved in drug resistance and propose possible strategies for improving drug treatments by altering the microenvironment.

“Agents that improve drug delivery or activity by targeting the tumor microenvironment … represent an important direction for cancer therapy,” the authors write.


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