University of Manchester researchers have identified a genetic variant in a region on chromosome 6 that is associated with rheumatoid arthritis (RA), the most common inflammatory arthritis affecting 387,000 people in the UK.
Researchers at Johns Hopkins have evidence to explain why the supposedly natural act of aging is by itself a very potent risk factor for life-threatening heart failure.
An international team of scientists, supported in part by the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), announced that its systematic effort to map the genomic changes underlying lung cancer has uncovered a critical gene alteration not previously linked to any form of cancer. The research, published in the advance online issue of the journal Nature, also revealed more than 50 genomic regions that are frequently gained or lost in lung adenocarcinoma, the most common type of lung cancer in the United States.
SMA is the second most prevalent genetic cause of infant death in the UK, after cystic fibrosis. Studies show that between 1:50 and 1:34 of the population are carriers of the disease, and that it affects in the region of 1:10,000 children born in the UK. In the USA, 1:40 are carriers and 1:6,000 children are affected by the disease.
Treatment should be offered to all people with a particular rare lung condition, regardless of whether or not they show symptoms of it, say researchers and doctors behind a new study published today.
People older than 60 with high blood pressure are less likely than other groups of patients to receive advice from their doctors about lifestyle modifications that can help lower their blood pressure, a study by UNC researchers concludes.
Despite the availability of life-saving antiretroviral treatment, people infected with HIV (human immunodeficiency virus) continue to die and suffer from complications of AIDS, mainly due to delayed diagnosis and initiation of treatment. A researcher at the Albert Einstein College of Medicine of Yeshiva University and colleagues at Yale University have shed light on why this problem persists. They report their findings in the November issue of the journal Medical Care.
Liver cirrhosis is a worldwide disease with an incidence of 5 – 10% and represents a major health problem everywhere. Prognosis depends on the degree of liver damage and etiology of cirrhosis. Treatment is complex and often very expensive. Due to this, the attempts of researchers are focused on finding the most optimal therapeutic modalities, which depend mostly on the stage of cirrhosis.
Severe acute pancreatitis (SAP) is a fatal systemic disease featuring acute onset, serious conditions, high incidence of complications and 20 – 30% mortality, mainly due to multiple organ failure at its early stage. The pathogenesis of SAP is closely related to factors such as activation of pancreatin, release of inflammatory mediators, microcirculation disturbance and apoptosis.
When a person learns they are suffering from cancer, the first question in their mind is always: “How much time do I have?” Unfortunately, this is a question to which the researchers have long been seeking an absolute answer. Tumor progression to local invasion and metastasis are the most relevant processes for prognosis, and predictive factors for survival are sometimes the only hope for cancer patients. Tumor suppressors and adhesion molecules represent one of the primary challenges in cancer therapy.