Purpura :: Eltrombopag decreased bleeding episodes and improved platelet counts in idiopathic thrombocytopenic purpura

GlaxoSmithKline (GSK) today announced additional results from an international Phase II short-term, six-week study of its investigational non-peptide oral platelet growth factor, eltrombopag. Analysis of data from this study showed that eltrombopag at 50mg or 75mg, resulted in a positive trend in decrease in bleeding incidence (all grades) in adult patients with chronic idiopathic thrombocytopenic purpura (ITP), an autoimmune condition which results in low blood platelet counts and bleeding from the small blood vessels. These data were presented today at the 48th Annual American Society of Hematology (ASH) meeting in Orlando, Florida.

Fertility :: Declining US fertility rates

In the United States, the total fertility rate — the number of children a woman has in her lifetime — fell from seven or eight in 1800 to slightly more than two today, says J. David Hacker, assistant professor of history at Binghamton University. And with a five-year $667,237 grant from the National Institute of Child Health and Human Development, Hacker hopes to find out why.

Baby Care :: Less help at home — Female support for new Moms on the decline

How is motherhood different than it was a century ago? In the past, live-in grandmothers, relatives and other women were frequently available to assist with childcare. But times have changed. New research by Brown University sociologist Susan E. Short shows that today’s mothers with young children are getting substantially less help around the house. Even when other women are living in the household, they aren’t necessarily on hand to help with the kids. This research appears in Demography.

Stem Cell :: Aldagen’s product to isolate cord blood stem cells

Interim data from a clinical trial using Aldagen’s product, ALDESORT? to isolate stem cells from cord blood was presented at the 48th Annual Meeting of the American Society of Hematology demonstrating improved safety and efficacy when using ALDESORT compared to the COBLT control group. The trial is being conducted by Joanne Kurtzberg, MD, the Duke University physician who pioneered the use of umbilical cord blood as treatment for fatal childhood cancers and genetic diseases.

Transplant :: Preventing graft-versus-host disease after bone marrow transplant

Most patients undergoing bone-marrow transplant must receive powerful chemotherapy drugs to suppress their immune system and prevent their bodies from rejecting the donated cells. New research shows that this chemotherapy increases the risk for graft-versus-host disease — but also suggests that this risk can be reduced by replacing a natural antibiotic that’s depleted when patients undergo chemotherapy. A multicenter study led by Children’s Hospital Boston and the Dana-Farber Cancer Institute is about to test this idea.

Hearing Loss :: Noisy Christmas toys can damage hearing

Many toys available this Christmas could damage your child’s hearing according to the UK-based charity Deafness Research UK.Working with researcher Dr. Brad Backus from University College London (UCL), the charity tested the noise levels produced by a selection of toys available to buy this Christmas.

Stem Cell :: Muscle and bone from an ink-jet printer

At the 2006 American Society for Cell Biology conference, scientists present the first research findings of a system that can pattern the formation of multiiple tissues from a single population of adult stem cells.

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