In a 28-year study of 261 Japanese-American men who carried Helicobacter pylori belonging to a large family or being born later in the family was associated with a significantly increased risk of developing gastric adenocarcinoma late in life.
In a 28 year study of 261 Japanese-American men who carried Helicobacter pylori belonging to a large family or being born later in the family was associated with a significantly increased risk of developing gastric adenocarcinoma late in life. These results suggest that early-life social environment plays a significant role in risk of microbially induced malignancies expressing five to eight decades later.
Citation: Blaser MJ, Nomura A, Lee J, Stemmerman GN, Perez-Perez GI (2007) Early-life family structure and microbially induced cancer risk. PLoS Med 4(1): e7.