Resilience :: Ability to handle stress, depression linked to brain mechanism

Results of a new study may one day help scientists learn how to enhance a naturally occurring mechanism in the brain that promotes resilience to psychological stress. Researchers funded by the National Institutes of Health’s National Institute of Mental Health (NIMH) found that, in a mouse model, the ability to adapt to stress is driven by a distinctly different molecular mechanism than is the tendency to be overwhelmed by stress. The researchers mapped out the mechanisms – components of which also are present in the human brain – that govern both kinds of responses.

Schizophrenia :: How schizophrenia develops, major clues discovered

Schizophrenia may occur, in part, because of a problem in an intermittent on/off switch for a gene involved in making a key chemical messenger in the brain, scientists have found in a study of human brain tissue. The researchers found that the gene is turned on at increasingly high rates during normal development of the prefrontal cortex, the part of the brain involved in higher functions like thinking and decision-making — but that this normal increase may not occur in people with schizophrenia.

Aging :: AFAR/Ellison Medical Foundation increase commitment to scientists studying aging

At a time when established scientists are leaving academia because of a lack of funding for biomedical research and a potential new generation of scientists are considering whether to even enter a field with a competitive funding environment, the Ellison Medical Foundation in partnership with the American Federation for Aging Research (AFAR), has increased funding for two critical grant programs: the new Ellison Medical Foundation/AFAR Postdoctoral Fellows in Aging Research Program and the Julie Martin Mid-Career Awards in Aging Research.

Alzheimer’s Disease :: New blood test to diagnose Alzheimer’s Disease

A team of international researchers reported they have identified a group of cell-signaling proteins found in blood that serve as a unique “voiceprint” that can not only be used to diagnose Alzheimer’s disease, but also classify and predict presymptomatic individuals who will eventually develop the memory-robbing disorder.

Health :: New insight into childhood metabolic disease

Glutaric acidemia type I (GA-I) is an inherited disorder similar to Huntington disease. Individuals with GA-I are unable to breakdown completely the amino acids lysine and tryptophan and the intermediates of lysine and tryptophan breakdown accumulate in the brain. In most, but not all, affected children, a period of normal development is followed by an irreversible brain injury triggered by a nonspecific illness.

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