Cystoplasty using gastrointestinal segments is a common treatment for patients with end-stage bladder disease.
However, researchers from Wake Forest University and Children?s Hospital Boston have reported viable results with engineered bladder tissue in a small group of patients with myelomeningocele (a type of spina bifida).
Using the patient?s own bladder tissue (obtained from biopsy), researchers grew urothelial and muscle cells and seeded them on collagen-based, bladder-shaped scaffolds. The bladder constructs were then used for reconstruction and implanted, some with an omental wrap. Overall follow up (ranging from 22 to 61 months, mean 46 months) showed a prompt return of bowel function, preserved renal function, normal mucus production and no urinary calculi. Results were best in those patients where implantation included an omental wrap.