Allergic conditions are on the rise in westernised countries and recent investigations have found that hospitalisations for anaphylaxis (a severe allergic reaction often involving more than one body system), urticaria (hives), and angioedema (allergic swelling of the face, lips and tongue) have been increasing since 1990.
Novartis and FDA notified healthcare professionals of changes to the WARNINGS and ADVERSE REACTIONS sections of the product labeling for Exjade, a drug used to treat chronic iron overload due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.
Investigators are presenting more than 380 abstracts on preliminary findings in the diagnosis and treatment of allergic diseases at the ACAAI Annual Meeting in Philadelphia, Nov. 9-15. Following are highlights of some key investigations on allergic rhinitis and ocular allergies.
Investigators are presenting more than 380 abstracts on preliminary findings in the diagnosis and treatment of allergic diseases at the ACAAI Annual Meeting in Philadelphia, Nov. 9-15. Following are highlights of some key investigations on anaphylaxis, food allergy and insect allergy.
Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), announced today that RLL has received tentative approval from the U.S. Food and Drug Administration to manufacture and market Cetirizine Hydrochloride Syrup, 5 mg/5 mL. Total annual market sales for Cetirizine Hydrochloride Syrup were $146.3 million (IMS ? MAT: June 2006).
Schering-Plough reported data from EPIC3, a large ongoing clinical study, showing that retreatment with PEG-INTRON(R) (peginterferon alfa-2b) and REBETOL(R) (ribavirin, USP) combination therapy can result in sustained virologic response(1) (SVR) in patients with chronic hepatitis C who failed previous treatment with any alpha interferon-based combination therapy, including peginterferon regimens. In this study, 56 percent of patients who had undetectable virus (HCV-RNA) after 12 weeks went on to achieve SVR with a 48-week course of therapy. Of the first 1,354 patients retreated, approximately 38 percent had undetectable virus at week 12. Importantly, patients who did not have undetectable virus at 12 weeks had little chance of achieving SVR. Overall, 23 percent of patients achieved SVR.
In medicine, a welt is a section of skin which is raised. It can also be referred to as a “wheal”. It may be caused by a blow or lash to the skin, by an allergic reaction, or by the injection of fluid via hypodermic syringe. If part of an allergic reaction, that itches intensely, it may be referred to as urticaria or hives.
Urticaria or hives is a relatively common form of allergic reaction that causes raised red skin welts.
Histamine and other pro-inflammatory substances are released from mast cells in the skin and tissues in response to the binding of allergen-bound IgE antibodies to high affinity cell surface receptors.
Mechanisms other than allergen-antibody interactions are known to cause histamine release from mast cells.