There is no antidote to the condition itself, but emergency medical clinicians can administer cyproheptadine or methysergide to control the symptoms. Doing so is important as the symptoms can in severe cases be potentially life threatening.
If the symptoms are not severe or life threatening, optimal treatment consists of discontinuation of the offending medication or medications, offering supportive measures, and waiting for the symptoms to resolve. If the offending medication is discontinued, the condition will often resolve on its own within 24 hours.