Dengue :: Dengue and other hemorrhagic fevers – Towards a first potential treatment
IRD immuno-virologists and their research partners have determined the mechanisms involved in the occurrence of the vascular leakage triggered by the Dengue virus. Metalloproteinases are responsible for the passage of plasma across the blood-vessel walls. These original results, validated first by in vitro tests then in vivo on a mouse model, open up the first line of attack for treatment against hemorrhagic Dengue and new perspectives for others hemorrhagic fevers, such as Ebola.