Cancer :: CD8+ T cells LAG behind

New data generated using mice by Charles Drake and colleagues at Johns Hopkins University School of Medicine, Baltimore, have identified a role for the protein LAG-3 in limiting the response of immune cells known as CD8+ T cells to both host and tumor proteins.

Breast Cancer :: Enhanced DNA repair mechanism can cause breast cancer

Although defects in the “breast cancer gene,” BRCA1, have been known for years to increase the risk for breast cancer, exactly how it can lead to tumor growth has remained a mystery. In the October 15, 2007, issue of the journal Cancer Research, scientists from the University of Chicago and Kyoto University, Japan, suggest that a mechanism that normally repairs damaged DNA may function abnormally in BRCA1 carriers leading to one type of poor-prognosis breast cancer.

Breast Cancer :: AACR, BCRF award inaugural grants in translational breast cancer research

Through the generous support of the Breast Cancer Research Foundation (BCRF), the American Association for Cancer Research (AACR) is pleased to announce the inaugural recipients of the 2007 BCRF-AACR Grants in Translational Breast Cancer Research. These grants provide direct support for innovative breast cancer research projects designed to accelerate the discovery, development, and application of new ways to treat breast cancer, or for preclinical research with direct therapeutic implications.

Prostate Cancer :: New research may show why some prostate cancer recurs after treatment

Cancer researchers have long worked to understand why some prostate cancers recur after the use of therapies designed to stop the production of testosterone and other androgens that fuel cancer cell growth. New research has now detected that androgen-synthesizing proteins are present within cancer cells, which suggests that cancer cells may develop the capacity to produce their own androgens.