During the mid 1990’s 2 early studies in South America showed high rates of efficacy for moclobemide in the treatment of Social Phobia (Social Anxiety Disorder).
Unfortunately, two larger North American studies in the late 1990’s showed no efficacy at all. While study data is conflicting, real world evidence is that moclobemide is no more effective in the treatment of SP (Social Phobia or Social Anxiety Disorder) than are the SSRI’s.
Moclobemide does have some advantages (and disavantages) relative to the SSRI’s. Moclobomide is equally effective as an antidepressant and causes no sexual side effects or sedation. However, moclobemide is less effective than the SSRI’s in the treatment of most anxiety disorders.